S3442

SB 216763

>98% (HPLC), glycogen synthase kinase-3 inhibitor

• Synonym(s): 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• Empirical Formula (Hill Notation): C₁₉H₁₂N₂O₂Cl₂
• CAS Number: 280744-09-4
• Molecular Weight: 371.22
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278616
• NACRES: NA.77
• MDL number: MFCD09753369
• Assay: >98% (HPLC)

Properties

• Product Name: SB 216763, >98% (HPLC)
• Quality Segment: 100
• assay: >98% (HPLC)
• color: orange
• solubility: DMSO: soluble 20 mg/mL, H₂O: insoluble
• originator: GlaxoSmithKline
• storage temp.: −20°C
• SMILES string: Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14
• InChI: 1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
• InChI key: JCSGFHVFHSKIJH-UHFFFAOYSA-N
• Gene Information: human ... GSK3A(2931), GSK3B(2932)

Description

Application

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line[1] and colorectal cancer cells.[2]

Biochem/physiol Actions

Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway.[3] It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.[4]

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves