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S1885

Suberic acid bis(N-hydroxysuccinimide ester)

≥95%, powder

Synonym(s):

Disuccinimidyl suberate, Disuccinimidyl octanedioate, Disuccinimidyl suberate (DSS)

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About This Item

Empirical Formula (Hill Notation):
C16H20N2O8
CAS Number:
Molecular Weight:
368.34
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥95%
Form:
powder
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Quality Level

assay

≥95%

form

powder

reaction suitability

reagent type: cross-linking reagent

solubility

chloroform: 50 mg/mL, DMF: soluble, aqueous buffer: slightly soluble (may require 5-10% organic solvent in coupling mixture.)

functional group

imide

storage temp.

2-8°C

SMILES string

O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O

InChI

1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2

InChI key

ZWIBGKZDAWNIFC-UHFFFAOYSA-N

General description

Suberic acid bis(N-hydroxysuccinimide ester) is a homobifunctional cross-linking reagent with amine reactivity. Typically coupled to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). Suberic acid bis(N-hydroxysuccinimide ester) incorporates an 8-atom linker.

Application

Suberic acid bis(N-hydroxysuccinimide ester) has been:
  • supplemented in pierce lysis buffer used for immunoprecipitation
  • used to conjugate the oligonucleotide standards to gelatin
  • used in cross-linking of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomers


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This Item
S5799M9794E3257
assay

≥95%

assay

≥95% (H-NMR)

assay

≥98%

assay

-

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

chloroform: 50 mg/mL, aqueous buffer: slightly soluble (may require 5-10% organic solvent in coupling mixture.), DMF: soluble

solubility

H2O: 10 mg/mL, soluble

solubility

chloroform: 100 mg/mL, DMF: soluble (lit.)(lit.)

solubility

acetic acid: water (1:1): ≤50 mg/mL, DMF: soluble

reaction suitability

reagent type: cross-linking reagent

reaction suitability

reagent type: cross-linking reagent

reaction suitability

reagent type: linker

reaction suitability

reagent type: cross-linking reagent


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Global Trade Item Number

SKUGTIN
S1885-500MG04061836915575
S1885-5G04061832750965
S1885-1G04061836915544

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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