P6249
p53 human
recombinant, expressed in E. coli, buffered aqueous glycerol solution
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About This Item
NACRES:
NA.25
UNSPSC Code:
12352202
Form:
buffered aqueous glycerol solution
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Pricing and availability is not currently available.
biological source
human
Quality Segment
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
buffered aqueous glycerol solution
UniProt accession no.
application(s)
genomic analysis
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TP53(7157)
General description
GST-tagged, full-length human p53
p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain. [1]
Application
Useful for the study of postranslational modification of p53, or protein-protein interaction studies.
Biochem/physiol Actions
p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.
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This Item | |||
|---|---|---|---|
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in baculovirus infected Sf21 cells | recombinant expressed in E. coli |
| biological source human | biological source human | biological source human | biological source human |
| assay ≥90% (SDS-PAGE) | assay ≥80% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay ≥80% (SDS-PAGE) |
| form buffered aqueous glycerol solution | form frozen liquid | form aqueous solution | form frozen liquid |
| shipped in wet ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| storage temp. −20°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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