Serotonin is generally considered to be unstable in solution. To assure optimum activity, it is recommended to use freshly prepared solutions. Note that the Certified Reference Material, product S-147, is a 1 mg/mL solution in Ethanol with 0.1% BHT. This item is stored at -65 to -96°C and assigned a retest schedule of 1 year from the date of quality release. Please see the link below to review a publication regarding the stability of Serotonin, that may be of interest:
https://www.sciencedirect.com/science/article/pii/S1386142504002604?via%3Dihub
H9523
Serotonin hydrochloride
≥98%, powder, neurotransmitter
Serotonin hydrochloride
Synonym(s):
3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C10H12N2O · HCl
CAS Number:
Molecular Weight:
212.68
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
3570963
Assay:
≥98%
Form:
powder
Pricing and availability is not currently available.
Product Name
Serotonin hydrochloride, powder
description
Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet
Quality Segment
assay
≥98%
form
powder
drug control
Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet
color
white to off-white
mp
149-154 °C (lit.)
solubility
H2O: 17 mg/mL, 0.1 M HCl: 22 mg/mL, ethanol: 5.3 mg/mL
storage temp.
2-8°C
SMILES string
Cl[H].NCCc1c[nH]c2ccc(O)cc12
InChI
1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
InChI key
MDIGAZPGKJFIAH-UHFFFAOYSA-N
Gene Information
human ... HTR3A(3359)
General description
Serotonin is a ubiquitous molecule found in all animals. It shows diverse effects in the central and peripheral nervous system (CAN/PNS). Serotonin acts as a hormone and as a mitogen.[1] It is produced in the axon terminal present in the brain. Action potential induces the release of serotonin that diffuses across the synapse to turn on the post-synaptic receptors. Serotonin plays a crucialrole in development, respiration, thermoregulation, endocrine, cardiovascular, and gastrointestinal functions. It also plays a role in sensory perceptional behaviors such as the sleep-wake cycle, sex, mood, memory, aggression, pain sensitivity, learning, and cognition. Serotonin impacts several psychiatric disorders such as schizophrenia, anorexia nervosa, depression, and a range of anxiety disorders such as obsessive-compulsive disorder, panic attacks, and social phobia. Variations in serotonin levels are associated withimpulse-related disorders or personalities like substance abuse, gambling, attention deficit disorder, obsessive-control, and aggression.[2]
Application
Serotonin hydrochloride hasbeen used: to study the mechanisms of 5-hydroxytryptamine receptor antagonistsregulate fibrosis in liver spheroids[3], to study its effects on theextracellular-related-kinase (ERK) phosphorylation in human embryonic kidneycells[4], in transwell assay, wound healing assay and tumor allograft assay incolon carcinoma cell line[5]
Biochem/physiol Actions
Neurotransmitter.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Solutions should be freshly prepared.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder or crystals |
| assay ≥98% | assay - | assay ≥95% (HPLC) | assay ≥98% (HPLC) |
| drug control Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet | drug control - | drug control - | drug control - |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp |
| solubility H2O: 17 mg/mL, ethanol: 5.3 mg/mL, 0.1 M HCl: 22 mg/mL | solubility 0.1 M HCl: soluble (Solutions should be freshly prepared.), 95% ethanol: very slightly soluble (Solutions should be freshly prepared.), absolute ethanol: insoluble | solubility H2O: 5 mg/mL, clear | solubility H2O: 15 mg/mL, clear |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| H9523-100MG | 04061835253340 |
| H9523-250MG | 04061835253364 |
| H9523-25MG | 04061835253371 |
| H9523-1G | 04061835253357 |
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How long can I keep 5-HT solution at 4oC?
1 answer-
Helpful?
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Is there any information of product H9523, as an agonist of h5HT7 receptor?
1 answer-
This product is known as an agonist of the 5-HT7 receptor. The following citation may be of interest for reference: Experimental Physiology 105.12 (2020): 2025-2032.
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Hello, what colour is the solution supposed to be when dissolved? Best, Anaïs
1 answer-
When prepared in water at 100 mg/mL, this material is expected to be clear to very slightly hazy in solution. While there is no specification for the color,
historical records indicate a range of faint yellow to light brown in solution.Helpful?
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Can it be stored -20C
1 answer-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
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Is Product H9523, Serotonin hydrochloride, the neurotransmitter serotonin?
1 answer-
This product is the neurotransmitter serotonin. Other synonyms for this product are 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, and 5-Hydroxytryptamine hydrochloride.
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What is the purity of Product H9523, Serotonin hydrochloride?
1 answer-
This product must be at least 98% pure according to our specifications. The purity for individual lots can be found on the certificate of analysis.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Has Product H9523, Serotonin hydrochloride, been cell culture tested?
1 answer-
No. We do not test this product for cell culture suitability.
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