This product is intended for research use only. In vitro and in vivo studies have been conducted for research purposes. This product has been cited in a number of publications. Please see the link below to review the current peer reviewed papers:
https://www.sigmaaldrich.com/US/en/search/d047?focus=papers&page=1&perpage=30&sort=relevance&term=D047&type=citation_search
D047
(±)-SKF-38393 hydrochloride
≥98% (HPLC), D1 dopamine receptor agonist, crystalline
Synonym(s):
(±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C16H17NO2 · HCl
CAS Number:
Molecular Weight:
291.77
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
crystalline
Storage condition:
desiccated, protect from light
Pricing and availability is not currently available.
Product Name
(±)-SKF-38393 hydrochloride, crystalline, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
crystalline
storage condition
desiccated, protect from light
color
white
solubility
H2O: >5 mg/mL, aqueous base: soluble (unstable)
SMILES string
Cl.Oc1cc2CCNCC(c3ccccc3)c2cc1O
InChI
1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H
InChI key
YEWHJCLOUYPAOH-UHFFFAOYSA-N
Gene Information
human ... DRD1(1812)
Application
(±)-SKF-38393 hydrochloride has been used as a selective D1 receptor agonist as a part of dopaminergic treatment. It has also been used to study its effect on prolactin in male baboons.
Biochem/physiol Actions
(±)-SKF-38393 is a D1 dopamine receptor agonist. It is known to promote the production of glutamate in the hippocampus.
Disclaimer
This material is hygroscopic. Air-sensitive. Light-sensitive.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form crystalline | form solid | form solid | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: >5 mg/mL, aqueous base: soluble (unstable) | solubility H2O: >5 mg/mL | solubility DMSO: >20 mg/mL, H2O: insoluble | solubility H2O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL |
| storage condition desiccated, protect from light | storage condition desiccated, protect from light | storage condition - | storage condition desiccated |
| Gene Information human ... DRD1(1812) | Gene Information human ... DRD1(1812) | Gene Information human ... DRD1(1812) | Gene Information human ... DRD1(1812) |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| D047-1G | 04061825982144 |
| D047-500MG | 04061832090054 |
| D047-100MG | 04061833557693 |
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is this crossed the preclinical studies as in invitro and invivo for parkinson's disease
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