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Key Documents

90101

Sigma-Aldrich

Ampliflu Red

for fluorescence, ≥98.0% (HPLC)

Synonym(s):

10-Acetyl-3,7-dihydroxyphenoxazine

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About This Item

Empirical Formula (Hill Notation):
C14H11NO4
CAS Number:
Molecular Weight:
257.24
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.32

grade

for fluorescence

Quality Level

Assay

≥98.0% (HPLC)

form

powder

fluorescence

λex 571 nm; λem 585 nm in DMSO

storage temp.

2-8°C

SMILES string

CC(=O)N1c2ccc(O)cc2Oc3cc(O)ccc13

InChI

1S/C14H11NO4/c1-8(16)15-11-4-2-9(17)6-13(11)19-14-7-10(18)3-5-12(14)15/h2-7,17-18H,1H3

InChI key

PKYCWFICOKSIHZ-UHFFFAOYSA-N

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Application

Ampliflu Red has been used to study mitochondrial abnormalities and oxidative stress related to Parkinson’s Disease. Ampliflu Red assay was suitable as an alternative indicator assay for detecting the inhibition of hTPO (human thyroid peroxidase) activity. Phospholipase D, an essential cellular process ingredient, used Ampliflu Red (10-Acetyl-3,7-dihydroxyphenoxazine) to determine its activity.Ampliflu Red is used for the following applications:
  • Quantification of inflammatory mediators
  • Determination of free and esterified cholesterol contents
  • Evaluation of compounds as substrates for GABA-AT compounds

Legal Information

Ampliflu is a trademark of Sigma-Aldrich Co. LLC

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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thais Soprani Ayala et al.
Scientific reports, 9(1), 11447-11447 (2019-08-09)
Macrophages may be a crucial aspect of diabetic complications associated with the inflammatory response. In this study, we examined how hyperglycaemia, a common aspect of diabetes, modulates bone marrow-derived macrophages (BMDMs) under an inflammatory stimulus. To perform this study, BMDMs
Kazuo Sugiyama et al.
PloS one, 9(4), e94460-e94460 (2014-04-11)
Most of experiments for HCV infection have been done using lytic infection systems, in which HCV-infected cells inevitably die. Here, to elucidate metabolic alteration in HCV-infected cells in a more stable condition, we established an HCV-persistently-infected cell line, designated as
Barae Jomaa et al.
ALTEX, 32(3), 191-200 (2015-03-31)
A simple and rapid luminometric assay for the detection of chemical inhibitors of human thyroid peroxidase (hTPO) activity was developed and validated with 10 model compounds. hTPO was derived from the human thyroid follicular cell line Nthy-ori 3-1 and its
Maria Luisa Di Paolo et al.
Journal of enzyme inhibition and medicinal chemistry, 34(1), 740-752 (2019-03-05)
Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1-9) or methoctramine (10-14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and acetylpolyamine oxidase (PAOX). Compound 2 turned out to
Anne H van der Spek et al.
Endocrine connections, 6(8), 731-740 (2017-11-05)
Innate immune cells have recently been identified as novel thyroid hormone (TH) target cells in which intracellular TH levels appear to play an important functional role. The possible involvement of TH receptor alpha (TRα), which is the predominant TR in

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