7-(Diethylamino)coumarin-3-carboxylic acid

Name: 7-(Diethylamino)coumarin-3-carboxylic acid
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥98.0% (HPCE)

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₅NO₄

CAS Number:

50995-74-9

Molecular Weight:

261.27

UNSPSC Code:

12352106

NACRES:

NA.32

PubChem Substance ID:

57649663

MDL number:

MFCD00068721

Beilstein/REAXYS Number:

6145963

Key Documents

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InChI

1S/C14H15NO4/c1-3-15(4-2)10-6-5-9-7-11(13(16)17)14(18)19-12(9)8-10/h5-8H,3-4H2,1-2H3,(H,16,17)

SMILES string

CCN(CC)c1ccc2C=C(C(O)=O)C(=O)Oc2c1

InChI key

WHCPTFFIERCDSB-UHFFFAOYSA-N

product line

BioReagent

assay

≥98.0% (HPCE)

mp

222-224 °C (dec.) (lit.)

solubility

DMF: soluble, DMSO: soluble

fluorescence

λ_ex 409 nm; λ_em 473 nm in 0.1 M Tris pH 9.0

suitability

suitable for fluorescence

Quality Level

200

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This Item	21882	46935	72301
Sigma-Aldrich 36799 7-(Diethylamino)coumarin-3-carboxylic acid	Sigma-Aldrich 21882 5(6)-Carboxy-2′,7′-dichlorofluorescein	Sigma-Aldrich 46935 6-[Fluorescein-5(6)-carboxamido]hexanoic acid	Sigma-Aldrich 72301 9-(2-Carboxy-2-cyanovinyl)julolidine
suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence
fluorescence λ_ex 409 nm; λ_em 473 nm in 0.1 M Tris pH 9.0	fluorescence λ_ex 504 nm; λ_em 529 nm in 0.1 M Tris pH 8.0	fluorescence λ_ex 491 nm; λ_em 515 nm in 0.1 M Tris pH 9.0	fluorescence λ_ex 433 nm; λ_em 500 nm in 50 mM Tris pH 8.0; 40% glycerol
solubility DMF: soluble, DMSO: soluble	solubility DMF: soluble, DMSO: soluble, H₂O: soluble (pH ≥ 5)	solubility DMF: soluble, DMSO: soluble	solubility DMSO: soluble, chloroform: soluble
assay ≥98.0% (HPCE)	assay ≥95% (TLC)	assay ≥90% (HPCE)	assay ≥97.0% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 100
mp 222-224 °C (dec.) (lit.)	mp ≥250 °C (lit.)	mp -	mp -

Application

7-(Diethylamino)coumarin-3-carboxylic acid (7-DCCA) may be used to study its photophysical properties in various solvents and solvent mixtures and as a fluorescent label for amine modification and protein conjugation[1]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Fluorescent label for amine modification and protein conjugation[1]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Recombinant Chromosome 7 Driven by Maternal Chromosome 7 Pericentric Inversion in a Girl with Features of Silver-Russell Syndrome.

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Maternal uniparental disomy of chromosome 7 is present in 5-10% of patients with Silver-Russell syndrome (SRS), and duplication of 7p including GRB10 (Growth Factor Receptor-Bound Protein 10), an imprinted gene that affects pre-and postnatal growth retardation, has been associated with

Modulating physical properties of porcine urethra with injection of novel biomimetic proteoglycans ex vivo.

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Urinary incontinence is a significant challenge for women who are affected by it. We propose augmenting the tissue structure to restore normal biomechanics by molecularly engineering the tissue using a novel family of biomimetic proteoglycans (BPGs). This work examines the

Mechanism of interaction between single-stranded DNA binding protein and DNA.

Simone Kunzelmann et al.

Biochemistry, 49(5), 843-852 (2009-12-24)

A single-stranded DNA binding protein (SSB), labeled with a fluorophore, interacts with single-stranded DNA (ssDNA), giving a 6-fold increase in fluorescence. The labeled protein is the adduct of the G26C mutant of the homotetrameric SSB from Escherichia coli and a

The photophysics of 7-(N,N'-diethylamino)coumarin-3-carboxylic acid in water/AOT/isooctane reverse micelles: an excitation wavelength dependent study.

Chatterjee A, Maity B, Seth D.

Physical Chemistry Chemical Physics, 1894-1906 (2012)

Inhibition of the formation of amyloid beta-protein fibrils using biocompatible nanogels as artificial chaperones.

Keisuke Ikeda et al.

FEBS letters, 580(28-29), 6587-6595 (2006-11-28)

The formation of fibrils by amyloid beta-protein (Abeta) is considered as a key step in the pathology of Alzheimer's disease (AD). Inhibiting the aggregation of Abeta is a promising approach for AD therapy. In this study, we used biocompatible nanogels

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