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A-094

Ascomycin solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C43H69NO12
CAS Number:
104987-12-4
Molecular Weight:
792.01
NACRES:
NA.24
UNSPSC Code:
41116107
EC Number:
200-835-2
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grade

certified reference material

Quality Segment

300

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−70°C

SMILES string

CCC1\C=C(C)\CC(C)CC(OC)C2OC(O)(C(C)CC2OC)C(=O)C(=O)N3CCCCC3C(=O)OC(C(C)C(O)CC1=O)\C(C)=C\C4CCC(O)C(C4)OC

InChI

1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+

InChI key

ZDQSOHOQTUFQEM-AMASXYNMSA-N

General description

An internal standard for LC-MS/MS testing of the immunosuppressants tacrolimus, sirolimus, and everolimus. Certified Spiking Solutions® are suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the narrow therapeutic range of these immunosuppressants. The Snap-N-Spike® format provides laboratories the ability to spike into their matrix of choice just before use and allows them to eliminate weighing operations of hazardous substances which significantly reduces occupational exposure hazards related to handling acutely toxic powders such as immunosuppressants.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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application(s)

clinical testing

application(s)

clinical testing

application(s)

pharmaceutical (small molecule)

application(s)

clinical testing

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

form

liquid

form

liquid

form

liquid

form

liquid

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

grade

certified reference material

grade

certified reference material

grade

certified reference material

grade

certified reference material

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−70°C

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Certificates of Analysis (COA)

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Jingjing Xie et al.
Journal of medicinal chemistry, 52(11), 3516-3522 (2009-05-09)
We developed an in-cell NMR assay for screening small molecule interactor libraries (SMILI-NMR) for compounds capable of disrupting or enhancing specific interactions between two or more components of a biomolecular complex. The method relies on the formation of a well-defined
Germán Sierra-Paredes et al.
CNS neuroscience & therapeutics, 14(1), 36-46 (2008-05-17)
Ascomycin and FK506 are powerful calcium-dependent serine/threonine protein phosphatase (calcineurin [CaN], protein phosphatase 2B) inhibitors. Their mechanism of action involves the formation of a molecular complex with the intracellular FK506-binding protein-12 (FKBP12), thereby acquiring the ability to interact with CaN
Patrizia Ferraboschi et al.
The Journal of antibiotics, 65(7), 349-354 (2012-04-19)
Tacrolimus is an immunosuppressant macrolactam of fermentative origin. By means of HPLC, LC-MS and NMR analyses, coupled with the reference standard synthesis, the main impurities of tacrolimus bulk drug samples were identified and their chemical-physical properties reported. Known ascomycin and
View All Related Papers

Global Trade Item Number

SKUGTIN
5469004061833457337
A-094-1ML04061833326312

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