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MSQC8

SigmaMAb Antibody Drug Conjugate (ADC) Mimic

Antibody Cysteine-Fluorophore Conjugate Standard

Synonym(s):

Antibody Drug Conjugate

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352204
Clone:
-
Species reactivity:
-
Application:
—
Citations:
1
Pricing and availability is not currently available.
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recombinant

expressed in CHO cells

Quality Segment

200

antibody product type

primary antibodies

form

lyophilized powder

shipped in

wet ice

storage temp.

−20°C

General description

SigmaMab Antibody Drug Conjugate (ADC) Mimic, is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic conjugates SigmaMab (MSQC4), an IgG1 monoclonal antibody, to dansyl fluorophores via an LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves as the substitution for the toxic payload of a real ADC.

The ADC Mimic allows for safer and more consistent testing, making it the optimal product over real ADCs. It is also a more affordable product compared to real ADCs. With the help of this non-toxic product, LC-MS processes can be developed in a safer environment.

Application

Poster: Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Poster: LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Poster: LC-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC Mimic

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form

lyophilized powder

form

-

form

solid

form

solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

recombinant

expressed in CHO cells

antibody product type

primary antibodies

antibody product type

primary antibodies

antibody product type

-

antibody product type

-

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Storage Class

11 - Combustible Solids

wgk

WGK 3

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Questions

1–2 of 2 Questions  

  1. Is the primary sequence of the antibody available?

    1 answer

    1. SigmaMAb Antibody Drug Conjugate (ADC) Mimic consists of the human universal monoclonal antibody standard (Catalog Number MSQC4, an IgG1 monoclonal antibody) conjugated to dansyl fluorophores via an LC-SMCC crosslinker.

      The sequence of MSQC4 can be found in the user guide. Sequence Information:

      1. SigmaMAb Heavy Chain:
      EVQLVESGGGLVQPGGSLRLSCVASGFTLNNYD MHWVRQGIGKGLEWVSKIGTAGDRYYAGSVKGR FTISRENAKDSLYLQMNSLRVGDAAVYYCARGAG RWAPLGAFDIWGQGTMVTVSSASTKGPSVFPLA PSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQ TYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNS TYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPI EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLT CLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALH NHYTQKSLSLSPG

      2. SigmaMAb Light Chain:
      QSALTQPRSVSGSPGQSVTISCTGTSSDIGGYNF VSWYQQHPGKAPKLMIYDATKRPSGVPDRFSGS KSGNTASLTISGLQAEDEADYYCCSYAGDYTPGV VFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANK ATLVCLISDFYPGAVTVAWKADSSPVKAGVETTT PSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT HEGSTVEKTVAPTECS

      Helpful?

  2. Does MSQC8 (SigmaMAb Antibody Drug Conjugate (ADC) Mimic) has light chain lambda or gamma?

    1 answer

    1. This antibody has both lambda light chains and gamma heavy chains.

      Helpful?

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