The stability of this compound in solution has not been determined. However, other sources report that stock solutions prepared in DMSO may be stable for up to 1 year at –20 °C and up to 2 years at –80 °C. When diluted to working concentrations with aqueous medium or buffers, it is not recommended to store solutions for more that 1 day. This information has not been validated.
A1737
A922500
synthetic (organic), >95% (HPLC), Diacylglycerol acyltransferase inhibitor, powder
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About This Item
Empirical Formula (Hill Notation):
C26H24N2O4
CAS Number:
Molecular Weight:
428.48
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.77
Pricing and availability is not currently available.
Product Name
A922500,
biological source
synthetic (organic)
Quality Segment
assay
>95% (HPLC)
form
powder
mol wt
Mw 428.5
solubility
DMSO: 10 mg/mL, clear, colorless to greenish-yellow
storage temp.
−20°C
SMILES string
N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1
InChI
1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
InChI key
BOZRFEQDOFSZBV-DHIUTWEWSA-N
Application
A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.
Biochem/physiol Actions
Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC50 7 to 24 nM
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease. [1]
Physical form
A922500 is supplied as a crystalline solid.
Preparation Note
A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
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This Item | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) |
| assay >95% (HPLC) | assay ≥95% | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
| solubility DMSO: 10 mg/mL, clear, colorless to greenish-yellow | solubility DMF: 20 mg/mL, clear to slightly hazy, colorless to light yellow | solubility water: 50 mg/mL, clear, colorless to faintly yellow | solubility water: 50 mg/mL, clear, colorless to yellow |
| storage temp. −20°C | storage temp. - | storage temp. −20°C | storage temp. −20°C |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Once the compound is dissolved in DMSO, I prepared a dilution in serum-free DMEM. How long can I store it at 4 °C while maintaining its stability?
1 answer-
Helpful?
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What is the half life of the inhibitor
1 answer-
The half life of this inhibitor has not been determined.
Helpful?
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Hello, in your description sector, it says this product can be dissolved in ethanol. However I have checked other sources that say A922500 is insoluble in ethanol. Could you clarify this for me?
1 answer-
This product is tested for solubility in DMSO at 10 mg/mL. The material is less soluble in ethanol at approximately 200 ug/mL. In addition, this compound may be dissolved in dimethylformamide at 20 mg/mL.
Helpful?
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