![[β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-me-Tyr2, Arg8]-Vasopressin ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/171/970/51ec0a9f-bbad-4de6-8379-01abbe367b05/640/51ec0a9f-bbad-4de6-8379-01abbe367b05.png)
![[deamino-Cys1, Val4, D-Arg8]-Vasopressin ≥95%](/deepweb/assets/sigmaaldrich/product/structures/242/492/d66f6a61-e108-4db6-b155-90a4b56d99fc/640/d66f6a61-e108-4db6-b155-90a4b56d99fc.png)
![[β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-Et-Tyr2, Val4, Arg8]-Vasopressin ≥97% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/211/868/9f767e8a-1d43-43eb-bf83-0af2c58c08a2/640/9f767e8a-1d43-43eb-bf83-0af2c58c08a2.png)
![[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/215/222/82da3633-80ea-463d-8b55-e99fb8e442e0/640/82da3633-80ea-463d-8b55-e99fb8e442e0.png)
This product is not tested for in vivo or in vitro use. The half-life is not determined.
V2255
[β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-me-Tyr2, Arg8]-Vasopressin
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C52H74N14O12S2
CAS Number:
Molecular Weight:
1151.36
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥97% (HPLC)
Pricing and availability is not currently available.
Quality Level
assay
≥97% (HPLC)
solubility
H2O: soluble 1 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
COc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC2=O)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1
InChI
1S/C52H74N14O12S2/c1-78-32-16-14-31(15-17-32)25-35-46(73)63-36(24-30-10-4-2-5-11-30)47(74)61-34(18-19-40(53)67)45(72)64-37(26-41(54)68)48(75)65-38(29-79-80-52(27-43(70)60-35)20-6-3-7-21-52)50(77)66-23-9-13-39(66)49(76)62-33(12-8-22-58-51(56)57)44(71)59-28-42(55)69/h2,4-5,10-11,14-17,33-39H,3,6-9,12-13,18-29H2,1H3,(H2,53,67)(H2,54,68)(H2,55,69)(H,59,71)(H,60,70)(H,61,74)(H,62,76)(H,63,73)(H,64,72)(H,65,75)(H4,56,57,58)/t33-,34-,35-,36-,37-,38-,39-/m0/s1
InChI key
QVQOGNOOAMQKCE-ZTYVOHGWSA-N
Gene Information
human ... AVPR1A(552)
mouse ... AVPR1A(54140)
rat ... AVPR1A(25107)
Application
[Beta-Mercapto-beta,beta-cyclopentamethylenepropionyl1, O-me-Tyr2, Arg8]-Vasopressin was used to block Vasopressin (V1a) receptors and study the role of endothelin, vasopressin and angiotensin in regulating arterial pressure during anaesthesia in dogs.[1] The product was used as a test compound for studying the impact of arginine vasopressin and atriopeptin on chloride uptake in cultured Type-I astrocytes.[2]
Biochem/physiol Actions
[Beta-Mercapto-beta,beta-cyclopentamethylenepropionyl1, O-me-Tyr2, Arg8]-Vasopressin is a V1a vasopressin receptor antagonist also referred to as “Manning compound”. Vasopressin can stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.[3] It induces reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which increases the water permeability of collecting duct cells.[4]
Preparation Note
[Beta-Mercapto-beta,beta-cyclopentamethylenepropionyl1, O-me-Tyr2, Arg8] vasopressin dissolves in water at 1 mg/ml to yield a clear, colorless solution.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥97% (HPLC) | assay ≥95% | assay ≥97% (HPLC) | assay ≥95% (HPLC) |
| solubility H2O: soluble 1 mg/mL, clear, colorless | solubility 50% acetic acid: soluble 1 mg/mL, clear, colorless | solubility water: 1 mg/mL, clear, colorless | solubility H2O: soluble 20 mg/mL, clear, colorless |
| Gene Information human ... AVPR1A(552) | Gene Information human ... AVPR2(554) | Gene Information human ... AVPR1A(552), AVPR2(554), OXT(5020), OXTR(5021) | Gene Information human ... AVPR2(554) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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L Katay et al.
Neurochemical research, 23(6), 831-836 (1998-05-08)
Ion and water homeostasis in the CNS is subjected to a neuroendocrine control exerted by neuropeptides formed within the brain. In order to gain information on this neuroendocrine control of Cl- homeostasis, 36Cl- uptake was measured in cultured Type-I astrocytes
Ada C Felix-Ortiz et al.
PloS one, 7(5), e37313-e37313 (2012-05-23)
Valproic acid (VPA) has been used clinically as an anticonvulsant medication during pregnancy; however, it poses a neurodevelopmental risk due to its high teratogenicity. We hypothesized that midgestational (GD) exposure to VPA will lead to lasting deficits in social behavior
M Carrillo et al.
Neuroscience, 185, 85-96 (2011-04-05)
In the latero-anterior hypothalamus (LAH) increased glutamate and vasopressin (AVP) activity facilitate anabolic androgenic steroid (AAS)-induced offensive aggression. In addition, adolescent AAS treatment increases the strength of glutamate-mediated connections between the LAH and the brain nucleus of stria terminalis (BNST).
Global Trade Item Number
| SKU | GTIN |
|---|---|
| V2255-.5MG | 04061832821573 |
| V2255-1MG | 04061837480768 |
| V2255-.1MG | 04061832821559 |
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What is the half-life of the [β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-me-Tyr2, Arg8]-Vasopressin when injected intravenously?
1 answer-
Helpful?
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