SML0067

5-カルボキシ-8-ヒドロキシキノリン

≥97% (HPLC)

• 別名: 8-ヒドロキシ-5-キノリンカルボン酸
• 実験式（ヒル表記法）: C₁₀H₇NO₃
• CAS番号: 5852-78-8
• 分子量: 189.17
• MDL番号: MFCD18417145
• UNSPSCコード: 51111800
• PubChem Substance ID: 329825131
• NACRES: NA.77

特性

• アッセイ: ≥97% (HPLC)
• 形状: powder
• 色: white to brown
• 溶解性: DMSO: 10 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: OC(=O)c1ccc(O)c2ncccc12
• InChI: 1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
• InChI Key: JGRPKOGHYBAVMW-UHFFFAOYSA-N

詳細

アプリケーション

IOX1 has been used:

• To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy.
• In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling.
• to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.

生物化学的／生理学的作用

5-カルボキシ-8-ヒドロキシキノリンは、ヒストンデメチラーゼインヒビターです。2-オキソグルタル酸依存性ヒストンデメチラーゼのJMJD2(KDM4)ファミリーを阻害し、N-オキサリルグリシンと同じ部位に結合します。

IOX1 has an IC50 value as 200nM. IOX1 might be used in the treatment of β-thalassemia by α-globin downregulation.

特徴および利点

IOX1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable