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CGS-15943

Name: CGS-15943
Brand: SIGMA

≥98% (HPLC), Adenosine receptor antagonist, solid

Synonym(s):

9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₈ClN₅O

CAS Number:

104615-18-1

Molecular Weight:

285.69

UNSPSC Code:

12352202

PubChem Substance ID:

24277704

NACRES:

NA.77

MDL number:

MFCD01529897

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Pricing and availability is not currently available.

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Properties

Product Name

CGS-15943, solid

assay

≥98% (HPLC)

Quality Level

100

form

solid

color

white

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

room temp

SMILES string

Nc1nc2ccc(Cl)cc2c3nc(nn13)-c4ccco4

InChI

1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)

InChI key

MSJODEOZODDVGW-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)

Description

Application

CGS-15943 has been used as a non-selective adenosine receptor antagonist to study its effects on the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and hepatocellular carcinoma (HCC)[1]. It has also been used as a non-selective adenosine receptor antagonist to investigate the mechanism underlying adenosine inhibition on cholangiocarcinoma (CCA) cells.[2]

Biochem/physiol Actions

CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.[1]

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This Item	S4568	S6451	Z0153
Sigma-Aldrich C199 CGS-15943	Sigma-Aldrich S4568 SCH 58261	Sigma-Aldrich S6451 SCH-442416	Sigma-Aldrich Z0153 ZM 241385
form solid	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. -	storage temp. 2-8°C	storage temp. room temp
solubility DMSO: >10 mg/mL, H₂O: insoluble	solubility DMSO: soluble >10 mg/mL, H₂O: insoluble	solubility DMSO: ≥20 mg/mL	solubility DMSO: >15 mg/mL
color white	color off-white	color light tan to tan	color white to tan

ppe

Eyeshields, Gloves, type N95 (US)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000364481

0000216290

0000209086

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Biochemical characterization of the triazoloquinazoline, CGS 15943, a novel, non-xanthine adenosine antagonist.

M Williams et al.

The Journal of pharmacology and experimental therapeutics, 241(2), 415-420 (1987-05-01)

CGS 15943A, a triazoloquinazoline, is a potent and selective adenosine receptor antagonist as assessed by its effects on radioligand binding and adenosine-stimulated adenylate cyclase activity in guinea pig synaptoneurosomes. At the adenosine A-1 receptor labeled with [3H]cyclohexyladenosine, CGS 15943A had

Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles.

A C Ngai et al.

American journal of physiology. Heart and circulatory physiology, 280(5), H2329-H2335 (2001-04-12)

The purpose of this study was to investigate the receptor subtypes that mediate the dilation of rat intracerebral arterioles elicited by adenosine. Penetrating arterioles were isolated from the rat brain, cannulated with the use of a micropipette system, and luminally

Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.

Lazaros C Foukas et al.

The Journal of biological chemistry, 277(40), 37124-37130 (2002-07-30)

We investigated the effects of methylxanthines on enzymatic activity of phosphoinositide 3-kinases (PI3Ks). We found that caffeine inhibits the in vitro lipid kinase of class I PI3Ks (IC(50) = 75 microm for p110 delta, 400 microm for p110 alpha and

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Global Trade Item Number

SKU	GTIN
C199-25MG	04061833474914

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