860517P

C17 Ceramide (d18:1/17:0)

Avanti Research^™ - A Croda Brand

• Sinonimo/i: N-heptadecanoyl-D-erythro-sphingosine
• Formula empirica (notazione di Hill): C₃₅H₆₉NO₃
• Numero CAS: 67492-16-4
• Peso molecolare: 551.93
• Numero MDL: MFCD02259275
• Codice UNSPSC: 12352211
• NACRES: NA.25

Proprietà

• Stato: powder
• Confezionamento: pkg of 1 × 10 mg (860517P-10mg); pkg of 1 × 25 mg (860517P-25mg); pkg of 1 × 5 mg (860517P-5mg)
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand
• Tipo di lipide: sphingolipids
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC[C@]([H])(NC(CCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C35H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35(39)36-33(32-37)34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h28,30,33-34,37-38H,3-27,29,31-32H2,1-2H3,(H,36,39)/b30-28+/t33-,34+/m0/s1; ICWGMOFDULMCFL-QKSCFGQVSA-N

Descrizione

Descrizione generale

Ceramide synthesis is mediated either by the salvage pathway by the acylation of sphingosine or sphingolipids hydrolysis or by de novo pathway via dihydroceramide formation.[1] Structurally, ceramides have a sphingoid base, a long-chain amino alcohol linked to fatty acid by an amide bond.[2]

Applicazioni

C17 Ceramide (d18:1/17:0) has been used:

• as an internal standard for myocardial ceramide quantification using chromatography with negative ion electrospray ionization coupled to tandem mass spectrometry[3]
• as an internal standard in tandem mass spectrometry (MS/MS)[4]
• as a substrate for sphingomyelin synthase 2 enzyme[5]

Azioni biochim/fisiol

Ceramides play a key role in regulating various cellular processes like senescence and apoptosis.[1] They are directly involved in the proliferation and differentiation of skin cells and regulate skin barrier functionality.[2] Ceramide based analogs are potential anti-tumor agents and are regarded as tumor suppressor lipid.[6]

Confezionamento

5 mL Amber Glass Screw Cap Vial (860517P-10mg)

5 mL Amber Glass Screw Cap Vial (860517P-25mg)

5 mL Amber Glass Screw Cap Vial (860517P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3