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911690

Sigma-Aldrich

C5 Lenalidomide

≥95%

Sinonimo/i:

3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, E3 ligase ligand, Ligand for PROTAC® research

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100 MG
279,00 €

279,00 €

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100 MG
279,00 €

About This Item

Formula empirica (notazione di Hill):
C13H13N3O3
Numero CAS:
191732-70-4
Peso molecolare:
259.26
Numero MDL:
MFCD31692701
Codice UNSPSC:
12352101
NACRES:
NA.22

279,00 €

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ligand

C5 Lenalidomide

Livello qualitativo

100

Saggio

≥95%

Stato

powder

Impiego in reazioni chimiche

reagent type: ligand

Temperatura di conservazione

2-8°C

Stringa SMILE

NC1=CC=C2C(CN(C3CCC(NC3=O)=O)C2=O)=C1

InChI

1S/C13H13N3O3/c14-8-1-2-9-7(5-8)6-16(13(9)19)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6,14H2,(H,15,17,18)
WLUIQUZGNPAKRL-UHFFFAOYSA-N

Categorie correlate

Applicazioni

C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Altre note

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production

Targeted Protein Degradation by Small Molecules

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H361d,H373

Classi di pericolo

Repr. 2 - STOT RE 2

Organi bersaglio

Blood

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

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Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

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Certificati d'analisi (COA)

Lot/Batch Number
0000375893
0000375893
MKCM1381

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Articoli

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

Domande

Recensioni

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