P0018

Pomalidomide

≥98% (HPLC), powder, HbF inducer

• Sinonimo/i: 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3
• Formula empirica (notazione di Hill): C₁₃H₁₁N₃O₄
• Numero CAS: 19171-19-8
• Peso molecolare: 273.24
• Numero MDL: MFCD12756407
• Codice UNSPSC: 12352200
• ID PubChem: 329819974
• NACRES: NA.77

Proprietà

• product name: Pomalidomide, ≥98% (HPLC)
• ligand: pomalidomide
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Impiego in reazioni chimiche: reagent type: ligand
• Colore: yellow
• Solubilità: DMSO: ≥14 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• InChI: 1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18); UVSMNLNDYGZFPF-UHFFFAOYSA-N
• Informazioni sul gene: human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , RBX1(9978)

Descrizione

Applicazioni

Pomalidomide has been used:

• to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides
• for apoptosis studies and intracellular calcium analysis
• as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells

Azioni biochim/fisiol

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

Caratteristiche e vantaggi

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H360D
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable