T5425

Transforming Growth Factor-β3 human

≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture

• Szinonimák: hTGF-β3, TGF-β3
• MDL-szám: MFCD00213054
• UNSPSC kód: 12352202
• NACRES: NA.77

Tulajdonságok

• product name: Transforming Growth Factor-β3 human, TGF-β3, recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture
• biológiai forrás: human
• Minőségi szint: 100
• rekombináns: expressed in baculovirus infected Sf21 cells
• Teszt: ≥97% (SDS-PAGE)
• form: powder
• hatékonyság: 0.01-0.09 ng/mL ED₅₀/EC₅₀
• minőség: endotoxin tested
• molekulatömeg: predicted mol wt ~25 kDa
• kiszerelés: pkg of 2 μg
• tárolási körülmény: avoid repeated freeze/thaw cycles
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: <0.01 EU/μg
• UniProt elérési szám: P10600
• tárolási hőmérséklet: −20°C
• Géninformáció: human ... TGFB3(7043)

Leírás

Általános leírás

The TGFβ3 (transforming Growth Factor-β3) gene is mapped to human chromosome 14q24.3.

Alkalmazás

Transforming Growth Factor-β3 human has been used to study the role of TGF-β3 in healing tendon-to-bone insertion and in chondrogenic differentiation.

Biokémiai/fiziológiai hatások

TGF-β (transforming growth factor-β3) isoforms are significantly involved in inducing inflammatory responses. It is associated with vascular diseases, wound healing and ameliorating effect in venous leg ulcer. TGF-β3 has an antagonistic effect on TGF-β1 and reduces the degree of collagen type I deposition and fibroblast differentiation. As a result TGF-β3 might lead to ulcer chronicity due to hindered myofibroblasts formation. TGF-β is a key player in tumor formation and progression. Increased TGF-β3 expression is observed in cancer and adipose tissue fibrosis. TGF-β3 is crucial in tissue regeneration and scarless tissue repair.

TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analízis megjegyzés

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)