T0167

D-(+)-Trehalose dihydrate

from Saccharomyces cerevisiae, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

• Szinonimák: α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside
• Tapasztalati képlet (Hill-képlet): C₁₂H₂₂O₁₁ · 2H₂O
• CAS-szám: 6138-23-4
• Molekulatömeg: 378.33
• Beilstein: 5322018
• EC-szám: 202-739-6
• MDL-szám: MFCD00071594
• UNSPSC kód: 12352201
• PubChem Substance ID: 24899871
• NACRES: NA.75

Tulajdonságok

• Minőségi szint: 200
• biológiai forrás: Saccharomyces cerevisiae
• termékcsalád: BioReagent
• Teszt: ≥99%
• form: powder
• technika/technikák: cell culture | insect: suitable; cell culture | mammalian: suitable
• oldhatóság: H₂O: 50 mg/mL
• SMILES string: [H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
• Nemzetközi kémiai azonosító kulcs: DPVHGFAJLZWDOC-PVXXTIHASA-N

Leírás

Általános leírás

Trehalose is a non-reducing disaccharide, ubiquitously present in nature. It is used as a food preservative and also to retain enzymes, vaccines, cells and many other molecules. Trehalose is present as hemolymph sugar among the invertebrates.

Alkalmazás

D-(+)-Trehalose dihydrate has been used in a slow-freezing method for freezing rabbit oocytes. It has also been used in solid-surface vitrification (SSV) of in vitro-matured oocytes. It is suitable for use as a cryoprotectant in a variety of cell freezing media.

Biokémiai/fiziológiai hatások

Trehalose is essential for embryogenesis, carbon metabolism, photosynthesis and flowering in plants. It predominantly exists among the species that supports anhydrobiosis (life without water). It serves as a carbohydrate reserve in microorganisms and protects them from adverse conditions, such as heat, cold, dehydration, desiccation and oxidation. Trehalose acts as a chemical chaperone affecting protein folding. It is known to prevent amyloid generation and accummulation of β-amyloid in vitro. A similar effect of trehalose has been observed with huntingtin protein aggregation. Thus, it might serve as a protective agent in Alzheimer′s disease and Huntington′s disease.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)