SML1278

Geldanamycin Ready Made Solution

1 mg/mL, from Streptomyces hygroscopicus

• Szinonimák: 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
• Tapasztalati képlet (Hill-képlet): C₂₉H₄₀N₂O₉
• CAS-szám: 30562-34-6
• Molekulatömeg: 560.64
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• biológiai forrás: Streptomyces hygroscopicus
• Minőségi szint: 200
• Forma: DMSO solution
• tárolási körülmény: protect from light
• koncentráció: 1 mg/mL
• antibiotikus hatásspektrum: neoplastics
• Hatásmechanizmus: enzyme | inhibits
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• SMILES string: N1C2=CC(=O)C(=C(C[C@H](C[C@@H]([C@@H]([C@H](\C=C(\[C@@H]([C@H](\C=C/C=C(/C1=O)\C)OC)OC(=O)N)/C)C)O)OC)C)C2=O)OC
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
• Nemzetközi kémiai azonosító kulcs: QTQAWLPCGQOSGP-KSRBKZBZSA-N

Leírás

Általános leírás

Chemical structure: benzenoid

Alkalmazás

Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.

Biokémiai/fiziológiai hatások

Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1
• Lobbanási pont (F): 188.6 °F
• Lobbanási pont (C): 87 °C