S7817

Scriptaid

≥95%, solid

• Szinonimák: 6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide
• Tapasztalati képlet (Hill-képlet): C₁₈H₁₈N₂O₄
• CAS-szám: 287383-59-9
• Molekulatömeg: 326.35
• MDL-szám: MFCD00386477
• UNSPSC kód: 12352203
• PubChem Substance ID: 329824590
• NACRES: NA.77

Tulajdonságok

• biológiai forrás: synthetic (organic)
• Minőségi szint: 100
• Teszt: ≥95%
• form: solid
• mp: 160-161 °C
• oldhatóság: DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow; DMSO: 1 mg/mL; methanol: soluble
• tárolási hőmérséklet: −20°C
• SMILES string: ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23
• InChI: 1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
• Nemzetközi kémiai azonosító kulcs: JTDYUFSDZATMKU-UHFFFAOYSA-N

Leírás

Általános leírás

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Alkalmazás

Scriptaid has been used in post activation of oocytes and embryo culture.

Scriptaid was used to enhance transcriptional activity in cloning procedures by somatic cell nuclear transfer.^5,6

Biokémiai/fiziológiai hatások

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

Scriptaid inhibits the cell cycle progression of ovarian cancer cells by inducing arrest in G0/G1 and/or G2/M phase. Treatment of cells with scriptaid results in loss of mitochondrial membrane potential and increased acetylation of H3 and H4 histone tails.² Sciptaid induces expression of γ-globin in human erythroid progenitors via p38 signaling and may be a treatment option for sickle cell disease.³ It enhances the transcriptional activity and protein expression in mouse embryos. This is useful in producing cloned, inbred mouse embryos that develop normally into adulthood with regular reproductive ability.⁴

Tulajdonságok és előnyök

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Jogi információk

Sold under license of U.S. Patent No. 6,544,957.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)