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Merck

RAB0216

Sigma-Aldrich

Human HSP70 ELISA Kit

for serum, plasma, cell culture supernatant and urine

Szinonimák:

HSP70-1, Heat shock 70 kDa protein 1A

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

UNSPSC kód:
41116158
NACRES:
NA.32

faj reaktivitás

human

kiszerelés

kit of 96 wells (12 strips x 8 wells)

technika/technikák

ELISA: suitable
capture ELISA: suitable

bemenet

sample type plasma
sample type urine
sample type cell culture supernatant(s)
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2 ng/mL
standard curve range: 2.469-600 ng/mL

észlelési módszer

colorimetric

kiszállítva

wet ice

tárolási hőmérséklet

−20°C

Géninformáció

human ... HSPA4(3308)

Általános leírás

The Human HSP70 (heat shock protein 70) ELISA (enzyme-linked immunosorbent assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human HSP70 in serum, plasma, cell culture supernatants and urine. HSP70 is an important ATP-dependent cytosolic chaperone along with Hsp90. Hspa4 aids in the folding of several proteins and helps in protecting against cellular stresses such as rise in temperature. HSP70 maintains the function of the mitotic centrosome to coordinates bipolar mitotic spindle assembly. Hspa4 might compensate the loss of parkin function in mice by protecting the cells against proteolytic and mitochondrial stress. Therefore, it can serve as an important therapeutic agent for parkinson disease. Upregulation of HSPA4 is observed in parkin gene knockout mice. Hspa4 is known to be associated with tumor progression and offers resistance against many therapeutic agents. The gene is upregulated in many different types of cancer.

Immunogén

Recombinant Human HSP70

Alkalmazás

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Egyéb megjegyzések

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.
Leírás
Biztonsági adatlap

  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)Biztonsági adatlap

  • RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)Biztonsági adatlap

  • RABSTOP3ELISA Stop Solution (Item I)Biztonsági adatlap

  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)Biztonsági adatlap

  • RABWASH420X Wash Buffer (Item B)Biztonsági adatlap

Piktogramok

Corrosion

Figyelmeztetés

Warning

Figyelmeztető mondatok

Óvintézkedésre vonatkozó mondatok

Veszélyességi osztályok

Met. Corr. 1

Tárolási osztály kódja

8A - Combustible corrosive hazardous materials


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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Dokumentumtár megtekintése

Daniel Alcolea et al.
Neurology, 89(2), 178-188 (2017-06-09)
To analyze the clinical utility of 3 CSF biomarkers and their structural imaging correlates in a large cohort of patients with different dementia and parkinsonian syndromes within the spectrum of frontotemporal lobar degeneration (FTLD). We analyzed 3 CSF biomarkers (YKL-40
Jie Hong et al.
Biological trace element research, 159(1-3), 269-277 (2014-04-17)
The widespread application of lanthanoids (Lns) in manufacturing industries has raised occupational and environmental health concerns about the possible increased health risks to humans exposed to Lns in their working and living environments. Numerous studies have shown that exposures to
Bing Leng et al.
Neuroscience letters, 723, 134866-134866 (2020-02-29)
Cognitive decline is a common non-motor symptom of Parkinson disease (PD), and cellular prion protein (PrPC) has been suggested to play a role in this process. This study aimed to investigate the correlation between plasma exosomal prion protein and cognitive
Maria Augustyniak et al.
Ecotoxicology (London, England), 26(10), 1408-1418 (2017-10-24)
Long lasting exposure of animals to stressing factor may lead to the selection of population able to cope with the stressor at lower cost than unexposed individuals. The aim of this study was to assess whether 130-generational selection of a
Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization
Kudryavtsev VA, et al.
PLoS ONE, 12(3), e0173640-e0173640 (2017)

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