P0884

(±)-Propranolol hydrochloride

≥99% (TLC), powder, β-adrenoceptor antagonist

• Szinonimák: (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride, DL-Propranolol hydrochloride
• Tapasztalati képlet (Hill-képlet): C₁₆H₂₁NO₂ · HCl
• CAS-szám: 318-98-9
• Molekulatömeg: 295.80
• Beilstein: 4164259
• EC-szám: 206-268-7
• MDL-szám: MFCD00012558
• UNSPSC kód: 12352200
• PubChem Substance ID: 24277796
• NACRES: NA.77

Tulajdonságok

• Terméknév: (±)-Propranolol hydrochloride, ≥99% (TLC), powder
• Minőségi szint: 200
• Teszt: ≥99% (TLC)
• Forma: powder
• szín: white
• oldhatóság: ethanol: 10 mg/mL; DMSO: <14.5 mg/mL; H₂O: 50 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
• kezdeményező: AstraZeneca
• tárolási hőmérséklet: 2-8°C
• SMILES string: Cl.CC(C)NCC(O)COc1cccc2ccccc12
• InChI: 1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
• Nemzetközi kémiai azonosító kulcs: ZMRUPTIKESYGQW-UHFFFAOYSA-N
• Géninformáció: human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Leírás

Általános leírás

Propranolol hydrochloride is easily soluble in ethanol and water.

dissolve with heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.

Alkalmazás

(±)-Propranolol hydrochloride has been used:

• to determine whether autonomic nervous system mediated the promotive effect on skin microcirculation in rat
• as a non-selective β- receptor blocker to reduce the arrhythmogenic events
• to study its effect on oxygen-induced retinopathy in mice

Biokémiai/fiziológiai hatások

Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT₁/5-HT₂ serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.

Tulajdonságok és előnyök

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Vigyázat

Shelf-life of the solid is at least four years if stored protected from the uptake of moisture.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H302
• Óvintézkedésre vonatkozó mondatok: P264 - P270 - P301 + P312 + P330 - P501
• Veszélyességi osztályok: Acute Tox. 4 Oral
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Faceshields, Gloves