Ugrás a tartalomra
Merck

PHR1308

Supelco

Propranolol hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Szinonimák:

(±)-Propranolol hydrochloride, (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride, DL-Propranolol hydrochloride

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

Tapasztalati képlet (Hill-képlet):
C16H21NO2 · HCl
CAS-szám:
Molekulatömeg:
295.80
Beilstein:
4164259
EC-szám:
MDL-szám:
UNSPSC kód:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Minőségi szint

Ügynökség

traceable to Ph. Eur. P3500000
traceable to USP 1576005

API-család

propranolol

Analitikai műbizonylat

current certificate can be downloaded

technika/technikák

HPLC: suitable
gas chromatography (GC): suitable

alkalmazás(ok)

pharmaceutical (small molecule)

Formátum

neat

tárolási hőmérséklet

2-30°C

SMILES string

Cl.CC(C)NCC(O)COc1cccc2ccccc12

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H

Nemzetközi kémiai azonosító kulcs

ZMRUPTIKESYGQW-UHFFFAOYSA-N

Géninformáció

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Általános leírás

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Propranolol is a β-adrenergic blocking compound, widely used for the management of cardiac arrhythmia, sinus tachycardia, angina pectoris and hypertension. It is also prescribed for the treatment of dysfunctional labor, migraine, as well as anxiety.

Alkalmazás

Propranolol hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by chromatography and spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analízis megjegyzés

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Egyéb megjegyzések

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Lábjegyzet

To see an example of a Certificate of Analysis for this material enter LRAA0068 in the slot below. This is an example certificate only and may not be the lot that you receive.

Javasolt termékek

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Piktogramok

Exclamation mark

Figyelmeztetés

Warning

Figyelmeztető mondatok

Veszélyességi osztályok

Acute Tox. 4 Oral

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

High-pressure liquid chromatographic method for the simultaneous quantitative analysis of propranolol and 4-hydroxypropranolol in plasma
Nation RI, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 145(3), 429-436 (1978)
Micellar liquid chromatographic determination of five antianginals in pharmaceuticals
Gil-Agusti M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(4), 1235-1242 (2006)
AAS and spectrophotometric determination of propranolol HCl and metoprolol tartrate
El-Ries MA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(2), 179-187 (2000)
Luca Filippi et al.
The Journal of pediatrics, 163(6), 1570-1577 (2013-09-24)
To evaluate safety and efficacy of oral propranolol administration in preterm newborns affected by an early phase of retinopathy of prematurity (ROP). Fifty-two preterm newborns with Stage 2 ROP were randomized to receive oral propranolol (0.25 or 0.5 mg/kg/6 hours)
Karina Haugaard Bendixen et al.
Journal of orofacial pain, 27(3), 243-255 (2013-07-25)
To investigate in a randomized, double-blinded, placebo controlled, crossover study the effect of a single dose of the nonselective β-adrenergic receptor antagonist propranolol (40 mg) on hypertonic saline (HS)-evoked masseter muscle pain and autonomic activity during rest and during a

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