I1771

Interleukin-13 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Szinonimák: IL-13
• CAS-szám: 148157-34-0
• MDL-szám: MFCD00212209
• UNSPSC kód: 12352202
• NACRES: NA.32

Tulajdonságok

• biológiai forrás: human
• Minőségi szint: 200
• rekombináns: expressed in E. coli
• Teszt: ≥97% (SDS-PAGE)
• Forma: lyophilized powder
• hatékonyság: <10.000 ng/mL ED₅₀
• molekulatömeg: 12 kDa
• kiszerelés: pkg of 10 μg
• technika/technikák: cell culture | mammalian: suitable
• szennyeződések: endotoxin, tested
• szín: white
• UniProt elérési szám: P35225
• tárolási hőmérséklet: −20°C
• Géninformáció: human ... IL13(3596)

Leírás

Biokémiai/fiziológiai hatások

IL-13 is known to be overexpressed in glioblastoma tumors and cell lines. Elevated IL-13 expression is also observed in parasitic infections. It stimulates fibrosis in many infectious diseases, and acts as a profibrogenic factor.

Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)