G8877

Guanosine 5′-triphosphate sodium salt hydrate

≥95% (HPLC), powder

• Szinonimák: GTP
• Tapasztalati képlet (Hill-képlet): C₁₀H₁₆N₅O₁₄P₃ · xNa⁺
• CAS-szám: 36051-31-7
• Molekulatömeg: 523.18 (free acid basis)
• Beilstein: 3585677
• EC-szám: 252-847-2
• MDL-szám: MFCD00077781
• UNSPSC kód: 41106305
• PubChem Substance ID: 24895354
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥95% (HPLC)
• Forma: powder
• szín: white
• oldhatóság: H₂O: 50 mg/mL
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• SMILES string: [Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H16N5O14P3.3Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1
• Nemzetközi kémiai azonosító kulcs: KZRMTEVIDYXWQW-CYCLDIHTSA-K
• Géninformáció: human ... HRAS(3265)

Leírás

Alkalmazás

Guanosine 5′-triphosphate sodium salt hydrate has been used:

• in the preparation of horseradish peroxidase (HRP)-modified platination reagents
• in whole cell, voltage-clamp recordings
• in in vitro inhibition of transglutaminase (tTG)

Biokémiai/fiziológiai hatások

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Tulajdonságok és előnyök

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Elkészítési megjegyzés

Prepared by enzymatic phosphorylation of 5′-GMP.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, type N95 (US)