G6649

Genistein

≥98% (HPLC), powder, tyrosine protein kinase inhibitor

• Szinonimák: 4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Tapasztalati képlet (Hill-képlet): C₁₅H₁₀O₅
• CAS-szám: 446-72-0
• Molekulatömeg: 270.24
• Beilstein: 263823
• EC-szám: 207-174-9
• MDL-szám: MFCD00016952
• UNSPSC kód: 12352200
• PubChem Substance ID: 24278036
• NACRES: NA.77

Tulajdonságok

• product name: Genistein, synthetic, ≥98% (HPLC), powder
• biológiai forrás: synthetic
• Minőségi szint: 200
• Teszt: ≥98% (HPLC)
• form: powder
• szín: off-white to yellow
• mp: 297.0-298.0 °C
• oldhatóság: DMSO: soluble; ethanol: soluble
• tárolási hőmérséklet: −20°C
• SMILES string: Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
• Nemzetközi kémiai azonosító kulcs: TZBJGXHYKVUXJN-UHFFFAOYSA-N
• Géninformáció: human ... AKT1(207) , CYP19A1(1588) , EGFR(1956) , ESR1(2099) , ESR2(2100) ; mouse ... Esr1(13982) , Hexa(15211) ; rat ... Adora1(29290) , Adora2a(25369) , Ar(24208)

Leírás

Általános leírás

Genistein is an isoflavonoid present among Leguminosae family of plants. It is structurally similar to estrogen (estradiol-17β).

Alkalmazás

Genistein has been used:

• as a test compound to access its estrogeniic acivity
• as an oestrogenic ligand to carry out identical reporter gene activation assays and also used to examine the binding of genistein to hERβ
• as an endocytosis inhibitor to test the possible effect of endocytosed advanced glycation end - bovine serum albumin (AGE-BSA) on lysosomes

Biokémiai/fiziológiai hatások

Genistein is essential for plant-microbe interaction. It acts as a natural chemoprotectant and helps in preventing tumor progression and heart disorders. Genistein functionally shares estrogen′s action. It is useful in evaluating nutraceuticals and functional foods. Genistein exhibits antimicrobial action and can serve as a phytoalexin and phytoanticipin.

Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.

Tulajdonságok és előnyök

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Chloride Channels and Met pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Elkészítési megjegyzés

Genistein is soluble in DMSO and ethanol. It is also soluble in chlorform:methanol (1:1 (v:v), 10 mg/ml).

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H302
• Óvintézkedésre vonatkozó mondatok: P264 - P270 - P301 + P312 - P501
• Veszélyességi osztályok: Acute Tox. 4 Oral
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, type N95 (US)