G6025

Geranylgeranyl pyrophosphate ammonium salt

solution, ≥95% (TLC), ~1 mg/mL in methanol: NH₄OH (7:3)

• Szinonimák: GGPP, all trans-3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl pyrophosphate ammonium salt
• Tapasztalati képlet (Hill-képlet): C₂₀H₃₆O₇P₂ · xNH₃
• CAS-szám: 6699-20-3
• Molekulatömeg: 450.44 (free acid basis)
• MDL-szám: MFCD00156114
• UNSPSC kód: 12352211
• PubChem Substance ID: 24895243
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥95% (TLC)
• form: solution
• kiszerelés: vial of 200 μg
• koncentráció: ~1 mg/mL in methanol: NH₄OH (7:3)
• tárolási hőmérséklet: −20°C
• SMILES string: C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
• InChI: 1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+
• Nemzetközi kémiai azonosító kulcs: OINNEUNVOZHBOX-QIRCYJPOSA-N

Leírás

Alkalmazás

Geranylgeranyl pyrophosphate ammonium salt has been used:

• in the preparation of 2.5X reaction buffer for Rab GGTase assay
• to add to the culture to further drive Hmg2 degradation
• as a substrate to carryout in vitro enzymatic assays for the characterization of the prenyltransferases
• to reverse the action of lovastatin and also used to examine the potential role of GGPP in the study to assess the effects of exposing the melanoma cell lines in the angiogenesis model as a co-culture to lovastatin in vitro

Biokémiai/fiziológiai hatások

Geranylgeranyl pyrophosphate (GGPP) is a major enzyme that participates in the secondary metabolism of chloroplast. GGPP synthase plays a key role in the biosynthesis of terpenoid. Protein geranylgeranylation, mediated by geranylgeranyl pyrophosphate participates in the development of the ventricular chamber. It also serves as a stage-specific signal to modulate the formation of cardiac cytoarchitecture the time of mid-gestation.

Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular weight G proteins, including Ras. Intermediate in terpene biosynthesis.

Tulajdonságok és előnyök

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Biztonsági adatok

• Piktogramok: GHS02,GHS06,GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H225,H301 + H311 + H331,H370
• Óvintézkedésre vonatkozó mondatok: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Veszélyességi osztályok: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Célzott szervek: Eyes
• Tárolási osztály kódja: 3 - Flammable liquids
• WGK: WGK 2
• Lobbanási pont (F): 51.8 °F - closed cup
• Lobbanási pont (C): 11 °C - closed cup
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter