G1404

Glutathione reduced ethyl ester

≥90% (TLC)

• Szinonimák: γ-Glu-Cys-Gly-OEt, GSH-MEE
• Tapasztalati képlet (Hill-képlet): C₁₂H₂₁N₃O₆S
• CAS-szám: 92614-59-0
• Molekulatömeg: 335.38
• MDL-szám: MFCD00156117
• UNSPSC kód: 12161504
• PubChem Substance ID: 329799840
• NACRES: NA.26

Tulajdonságok

• Terméknév: Glutathione reduced ethyl ester, ≥90% (TLC)
• Minőségi szint: 200
• Teszt: ≥90% (TLC)
• Forma: powder
• szín: white to off-white
• tárolási hőmérséklet: −20°C
• SMILES string: CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
• Nemzetközi kémiai azonosító kulcs: JKRODHBGNBKZLE-YUMQZZPRSA-N

Leírás

Amino Acid Sequence

Glu-Cys-Gly-OEt

Alkalmazás

Glutathione reduced ethyl ester has been used:

• to increase intracellular glutathione levels in mouse fibroblast L929 cells
• as a medium supplement in Spodoptera frugiperda (Sf)9 cells
• to evaluate its effect on lipid peroxidation after spinal cord injury

Biokémiai/fiziológiai hatások

Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.

Glutathione reduced ethyl ester inhibits melanin synthesis by inhibiting tyrosinase activity in Melan-A cells. Its antimelanogenic functionality has potential in treating hyperpigmentation skin disorders. GEE supplementation during islets isolation form pancreas reduces reactive oxygen species production and apoptosis.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)