Összes fotó(1)
Fontos dokumentumok
C3735
Cytochrome P450 human
1A1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
human
Minőségi szint
rekombináns
expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
Forma
solution
specifikus aktivitás
≥4 units/pmol enzyme
molekulatömeg
45-60 kDa
kiszerelés
vial of 0.5 nmol
technika/technikák
activity assay: suitable
oldhatóság
water: soluble
alkalmasság
suitable for molecular biology
UniProt elérési szám
alkalmazás(ok)
cell analysis
kiszállítva
dry ice
tárolási hőmérséklet
−70°C
Géninformáció
human ... CYP1A1(1543)
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Általános leírás
Research area: Immuno and CKS
Cytochrome P450 (CYP) enzymes are a family of enzymes that are encoded by the P450 genes. These enzymes are membrane bound hemoproteins. that are mainly found in the liver’s endoplasmic reticulum.
Cytochrome P450 (CYP) enzymes are a family of enzymes that are encoded by the P450 genes. These enzymes are membrane bound hemoproteins. that are mainly found in the liver’s endoplasmic reticulum.
Biokémiai/fiziológiai hatások
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous. The CYP1A1 isoform catalyzes 7-deethylation of ethoxyresorufin. Cytochrome P450 (CYP) plays an important role in detoxifying xenobiotics, cellular metabolism and homeostasis. One of the main mechanisms of drug-drug interactions is the induction or inhibition of these enzymes. CYP enzymes are transcriptionally activated by a variety of xenobiotics and by endogenous substrates via receptor-dependent pathways. Inhibition of these enzymes is a major factor in metabolism-based drug-drug interactions, and many chemotherapeutic medications can cause drug interactions by either inhibiting or inducing the cytochrome p450 enzyme system.
Fizikai forma
Solution in 100 mM potassium phosphate buffer, pH 7.4.
Elkészítési megjegyzés
Microsomes containing human CYP1A1 and recombinant human NADPH-P450 reductase.
Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 2
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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