H5042

Cytochrome P450 3A4 human

recombinant, expressed in E. coli

• Szinonimák: Cytochrome P450, purified, soluble, 1,4-cineole 2-exo-monooxygenase, Albendazole sulfoxidase, CYP3A3, CYP3A4, Cytochrome P450 NF-25, Cytochrome P450-PCN1
• CAS-szám: 9035-51-2
• UNSPSC kód: 12352204
• NACRES: NA.54

Tulajdonságok

• biológiai forrás: human
• Minőségi szint: 200
• rekombináns: expressed in E. coli
• leírás: purified, soluble
• Teszt: 3.5—25 mg protein/mL (Bradford)
• Forma: liquid
• specifikus aktivitás: 12-200 units/mg protein
• molekulatömeg: 57318.7 g/mol
• koncentráció: 3.5-25 mg protein/mL (protein); 50-150 nmol/mL (P450); 6-14 nmol/mg protein (specific content)
• technika/technikák: cell based assay: suitable
• oldhatóság: water: soluble
• NCBI elérési szám: NP_059488.2
• kiszállítva: dry ice
• tárolási hőmérséklet: −70°C
• Géninformáció: human ... CYP3A4(1576)

Leírás

Általános leírás

Research area: IMMUNO AND CKS

Cytochrome P450 3A4 (CYP3A4) indicates a mammalian enzyme (CYP) family 3, subfamily A, gene 4. There are 57 CYP genes and 33 pseudogenes in humans, organized into 18 families and 42 subfamilies. Among these, the 3A4 isoform (CYP3A4) is the most prevalent and is primarily found in the liver and gastrointestinal tract.

Alkalmazás

Cytochrome P450 3A4 human has been used in circular dichroism analysis.

Biokémiai/fiziológiai hatások

Cytochrome P450 3A4 (CYP3A4) is one of the isoforms of cytochrome P450 (P450s). Cytochrome P450s (P450s) plays a vital role in processing endogenous compounds and xenobiotics, including pollutants, environmental compounds, and drug molecules. CYP3A4 oxidizes more than 90% of marketed drugs through various metabolic processes.CYP3A4 mRNA expression is upregulated in pediatric Crohn’s disease. Moreover, it provides high tolerance against herbicides such as mefenacet, amiprofos-methyl, pyributicarb, norflurazon, trifluralin, pendimethalin, chlorotoluron, and chloroacetamides.

Egység definíció

One unit will convert 1.0 nanomole of testosterone to 6-beta-testosterone per minute at pH 7.4 at 37 °C.

Egyéb megjegyzések

Supplied as purified soluble proteins, rather than microsomal preparations.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable