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Fontos dokumentumok
MTOXCE1A2
CypExpress™ 1A2 Cytochrome P450 human
Szinonimák:
CP12, CYP1A2, P3-450, P450 1A2, P450(PA)
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
human
rekombináns
expressed in Pichia pastoris
Forma
dry powder
UniProt elérési szám
alkalmazás(ok)
cell analysis
kiszállítva
dry ice
tárolási hőmérséklet
−70°C
Géninformáció
human ... CYP1A2(1544)
Alkalmazás
Poster: A Novel, Robust Recombinant Human P450 Biocatalytic System
Poster: Evaluation of Dry Powder Preparations of Permeabilized
Pichia pastoris Cells Expressing Human Cytochrome P450 2D6 Enzyme (CYP2D6) for Drug Metabolite Generation
Poster: Facile Scale-up Biocatalytic Production of P-450 Metabolites Using a Novel Recombinant Human Catalytic System
Poster: Multi-Cycle Production of Metabolites with human P450 systems
Poster: Rapid identifcation and production of metabolites using CypExpress™ 2D6m 3A4 and 2C9
Poster: Rapid identifcation and production of metabolites using stabilized dried powder (SDP) of human cytochrome P450S (hCYPS) 2D6, 3A4, and 2C9 engineered in yeast
Poster: Utilizing a Novel Biocatalytic Human P450 System for the Multi - Cycle Production of Metabolites
Poster: Evaluation of Dry Powder Preparations of Permeabilized
Pichia pastoris Cells Expressing Human Cytochrome P450 2D6 Enzyme (CYP2D6) for Drug Metabolite Generation
Poster: Facile Scale-up Biocatalytic Production of P-450 Metabolites Using a Novel Recombinant Human Catalytic System
Poster: Multi-Cycle Production of Metabolites with human P450 systems
Poster: Rapid identifcation and production of metabolites using CypExpress™ 2D6m 3A4 and 2C9
Poster: Rapid identifcation and production of metabolites using stabilized dried powder (SDP) of human cytochrome P450S (hCYPS) 2D6, 3A4, and 2C9 engineered in yeast
Poster: Utilizing a Novel Biocatalytic Human P450 System for the Multi - Cycle Production of Metabolites
Biokémiai/fiziológiai hatások
Cytochrome P450 enzymes are heme containing monooxygenases which are found primarily in the mammalian liver. They catalyze the oxidative metabolism of xenobiotics. This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body. Furafylline and α-naphthoflavone are inhibitors, whereas omeprazole and lansoprazole are inducers of the enzyme. The isozyme CYP1A2 is a major pathway for the in vivo conversion of phenacetin into acetaminophen via O-deethylation. This isozyme also catalyzes the 5-hydroxylation of thiabendazole.
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous.
Tulajdonságok és előnyök
CypExpress™ 1A2 is a permeabilized and stabilized dried yeast powder preparation containing full length, unmodified, human CYP 1A2 and recombinant human NADPH oxidoreductase. Using proprietary processes, CypExpress™ are expressed in Pichia yeast. Following optimal expression, the cells are inactivated, permeabilized and dried to a fine powder. CypExpress™ retains the cellular mechanisms to provide the P450 enzymes with the energy and cofactors to continue to function for long experiments, and can generate larger amounts of metabolite than mammalian microsomes or other genetically engineered expression systems. It is designed for rapid screening of drug metabolites and for scaling up metabolite generation.
Egység definíció
A reaction mixture containing 500 μM phenacetin and 100 mg/mL of CypExpress™ 1A2 will produce 35 μM acetaminophen in 4 hours at 30°C under the conditions described.
Fizikai forma
Light yellow, very fine powder
Feloldás
Per Protocol/Variable
Jogi információk
CypExpress is a trademark of Oxford Biomedical Research
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Az ügyfelek ezeket is megtekintették
Chapter 4 - Oxidant Stress, Antioxidant Defense, and Liver Injury
Mitchell R.McGill and HartmutJaeschke
Drug-Induced Liver Disease (2013)
Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.
D Sesardic
British Journal of Clinical Pharmacology (1990)
Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction
Laura Lowe Furge and F. Peter Guengerich
Current Protocols in Cell Biology (2006)
R.Scott ObachA.S.Kalgutkar
Comprehensive Toxicology (2010)
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