C0858
Cyclooxygenase 2 human
≥70% (SDS-PAGE), recombinant, expressed in insect cells, aqueous solution, ≥8000 units/mg protein
Szinonimák:
COX-2, Prostaglandin H synthase 2
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
rekombináns
expressed in insect cells Active recombinant N-terminal His-tagged COX-2 N580A mutant purified from insect cells.
expressed in insect cells
Minőségi szint
Teszt
≥70% (SDS-PAGE)
Forma
aqueous solution
specifikus aktivitás
≥8000 units/mg protein
molekulatömeg
dimer subunit mol wt 70-74 kDa
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−70°C
Géninformáció
human ... PTGS2(5743)
Biokémiai/fiziológiai hatások
COX-2 catalyzes the conversion of arachidonic acid to prostaglandin H2 (the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins). It is the inducible form of cyclooxygenase, induced by phorbol esters, lipopolysaccharides, and cytokines. COX-2 is upregulated in the neovasculature of malignant tumors. Inhibition of COX-2 with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with decreased tumor growth.
Egyéb megjegyzések
Tagged with a six-residue histidine sequence near the N-terminus.
Egység definíció
One unit will consume 1.0 nanomole of oxygen per minute at pH 8 at 37 °C.
Fizikai forma
Solution in 80 mM Tris, pH 8.0, with 0.3 mM DDC, 0.01% TWEEN® 20 and 10% glycerol
Szubsztrátok
KM for arachidonate = 6.5 μM. Exhibits activity and sensitivity to NSAIDs similar to the non-tagged enzyme.
Jogi információk
TWEEN is a registered trademark of Croda International PLC
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
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