H7039

3-Hydroxy-3-methylglutaryl-CoA reductase human

solution

• Szinonimák: HMGCoA Reductase, HMGR
• Enzyme Commission szám: 1.1.1.34 (BRENDA, IUBMB)
• UNSPSC kód: 12352204
• NACRES: NA.54

Tulajdonságok

• Teszt: ≥90% (SDS-PAGE)
• Minőségi szint: 200
• Forma: solution
• specifikus aktivitás: 2-8 units/mg protein
• molekulatömeg: ~76 kDa (for the fusion protein)
• UniProt elérési szám: P04035
• kiszállítva: dry ice
• tárolási hőmérséklet: −70°C
• Géninformáció: human ... HMGCR(3156)

Leírás

Alkalmazás

3-Hydroxy-3-methylglutaryl-CoA reductase human has been used:

• in anti-HMGCR enzyme linked immunosorbent assay (ELISA)
• as an antigen to measure anti-HMGCR antibodies by blot analysis
• in HMG-CoA reductase activity assays
• as an antigen to compare in-house antigen via sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)/western blot

Biokémiai/fiziológiai hatások

3-Hydroxy-3-methylglutaryl-CoA reductase/HMGCR serves as a rate limiting enzyme in mevalonate pathway. It also controls the oncogenic Hippo transducers TAZ/YAP. HMGCR also perform as a genetic modifier for Alzheimer′s disease (AD).

Hydroxy-3-methylglutaryl-CoA reductase catalyzes the committed step in cholesterol biosynthesis.

Fizikai tulajdonságok

Consists of the HMG CoA reductase catalytic domain fused to GST protein.

Egység definíció

One unit will convert 1.0 μmole of NADPH to NADP⁺ per minute at 37 °C.

Fizikai forma

Supplied as a solution containing 250 μg protein in 50 mM Tris pH 7.5, with 5 mM DTT, 1:200 Protease Inhibitor Cocktail (Catalog Number P8340) and 50% (w/v) glycerol.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable