B1427

H-89 dihydrochloride hydrate

≥98% (HPLC), powder, PKA inhibitor

• Szinonimák: N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride
• Tapasztalati képlet (Hill-képlet): C₂₀H₂₀BrN₃O₂S · 2HCl · xH₂O
• CAS-szám: 130964-39-5
• Molekulatömeg: 519.28 (anhydrous basis)
• MDL-szám: MFCD11045926
• UNSPSC kód: 12352200
• PubChem Substance ID: 24278256
• NACRES: NA.77

Tulajdonságok

• Terméknév: H-89 dihydrochloride hydrate, ≥98% (HPLC), powder
• biológiai forrás: synthetic (organic)
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• szín: off-white
• oldhatóság: DMSO: 10 mg/mL, clear
• tárolási hőmérséklet: 2-8°C
• SMILES string: O.Cl.Cl.Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
• InChI: 1S/C20H20BrN3O2S.2ClH.H2O/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;;/h1-10,12,15,22,24H,11,13-14H2;2*1H;1H2/b3-2+;;;
• Nemzetközi kémiai azonosító kulcs: GKFFJFGBWAGAFD-HZBIHQSRSA-N
• Géninformáció: human ... PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)

Leírás

Alkalmazás

H-89 dihydrochloride hydrate has been used in the inhibition of protein kinase A in Leydig cells, primary calvarial osteoblasts (pOBs), rat granulosa cell line (LH-15 cells) and human umbilical vein endothelial cells (HUVECs).

Biokémiai/fiziológiai hatások

H-89 dihydrochloride hydrate is a selective inhibitor of protein kinase A (PKA). It also inhibits potassium (K⁺) current in rat myocytes. It mediates Na⁺ transport by interacting with α subunits of epithelial Na⁺ channel (ENaC).

Selective, potent inhibitor of cAMP-dependent protein kinase.

Tulajdonságok és előnyök

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PKA & PKG and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)