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K3394

Sigma-Aldrich

KH7

≥98% (HPLC)

Szinonimák:

(E)-2-(1H-Benzo[d]imidazol-2-ylthio)-N′-(5-bromo-2-hydroxybenzylidene)propanehydrazide

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About This Item

Tapasztalati képlet (Hill-képlet):
C17H15BrN4O2S
CAS-szám:
330676-02-3
Molekulatömeg:
419.30
MDL-szám:
MFCD01230899
UNSPSC kód:
41106305
PubChem Substance ID:
329817136
NACRES:
NA.77

Minőségi szint

100

Teszt

≥98% (HPLC)

form

powder

oldhatóság

DMSO: >20 mg/mL

tárolási hőmérséklet

2-8°C

SMILES string

CC(Sc1nc2ccccc2[nH]1)C(=O)N\N=C\c3cc(Br)ccc3O

InChI

1S/C17H15BrN4O2S/c1-10(25-17-20-13-4-2-3-5-14(13)21-17)16(24)22-19-9-11-8-12(18)6-7-15(11)23/h2-10,23H,1H3,(H,20,21)(H,22,24)/b19-9+

Nemzetközi kémiai azonosító kulcs

WILMXUAKQKGGCC-DJKKODMXSA-N

Alkalmazás

KH7 has been used:
  • as a soluble adenyl cyclase (sAC) antagonist to study its effect on the signaling pathway mediated by the action of transient  receptor type 1 (TRPV1) in sperm cells.
  • as a selective sAC antagonist to study its effect on the signaling pathway of proton gated channels (HV1) induced action in sperm cells.
  • as a sAC inhibitor to study its effects on cAMP increase in monophosphorylated myosin light chain (pMLC).

Biokémiai/fiziológiai hatások

KH7 is a selective inhibitor of soluble adenylyl cyclase. Soluble adenylyl cyclase (sAC) is an ubiquitously expressed, essential component of cAMP-signaling.

Tulajdonságok és előnyök

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Alkalmasság

KH7 is not active against sAC in the presence of detergents. When used in cellular experiments, KH7 exhibits non-specific membrane disruption effects at concentrations above 50 μM.

Piktogramok

Skull and crossbones
GHS06

Figyelmeztetés

Danger

Figyelmeztető mondatok

H301

Óvintézkedésre vonatkozó mondatok

P264 - P270 - P301 + P310 - P405 - P501

Veszélyességi osztályok

Acute Tox. 3 Oral

Tárolási osztály kódja

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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CBR-5884 ≥98% (HPLC)

Sigma-Aldrich

SML1656

CBR-5884

CREB Inhibitor, 666-15

Sigma-Aldrich

5.38341

CREB Inhibitor, 666-15

Forskolin from Coleus forskohlii, ≥98% (HPLC), powder

Sigma-Aldrich

F6886

Forskolin

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Discover Bioactive Molecules for Nucleotides

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