B5386

8-Bromoadenosine 3′,5′-cyclic monophosphate

≥97% (HPLC), powder, protein kinase A activator

• Szinonimák: 8-Br-A-3:5-MP, 8-Br-cAMP, 8-Bromo-cAMP
• Tapasztalati képlet (Hill-képlet): C₁₀H₁₁BrN₅O₆P
• CAS-szám: 23583-48-4
• Molekulatömeg: 408.10
• Beilstein: 591930
• EC-szám: 245-760-6
• MDL-szám: MFCD00075580
• UNSPSC kód: 41106305
• PubChem Substance ID: 24891835
• NACRES: NA.77

Tulajdonságok

• product name: 8-Bromoadenosine 3′,5′-cyclic monophosphate, ≥97% (HPLC)
• Minőségi szint: 200
• Teszt: ≥97% (HPLC)
• form: powder
• mp: 254 °C (dec.) (lit.)
• oldhatóság: aqueous base: soluble, clear
• tárolási hőmérséklet: −20°C
• SMILES string: Nc1ncnc2n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c(Br)nc12
• InChI: 1S/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1
• Nemzetközi kémiai azonosító kulcs: DVKQVRZMKBDMDH-UUOKFMHZSA-N

Leírás

Alkalmazás

8-Bromoadenosine 3′,5′-cyclic monophosphate has been used:

• to treat H295R cells as positive controls for CYP19 induction
• as a membrane permeable cAMP analog to study its effect on short-circuit current (I_sc)
• to investigate its potential as an inducer of differentiation in Wharton′s jelly-derived mesenchymal stem cells (WJ-MSCs)

Biokémiai/fiziológiai hatások

8-Bromoadenosine 3′,5′-cyclic monophosphate is a cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. 8-Bromoadenosine 3′,5′-cyclic monophosphate activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

8-bromo-adenosine 3′,5′-cyclic monophosphate (8-bromo-cAMP), added to hepatocytes during plating helps to increase the acquisition of beta-adrenoceptors.

Tulajdonságok és előnyök

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Egyéb megjegyzések

8-Bromoadenosine 3′,5′-cyclic monophosphate is a membrane-permeable cAMP analog.

Sensitive to light and moisture

Vigyázat

Sensitive to light and moisture.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)