L9908

LY-294,002 hydrochloride

from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor

• Szinonimák: 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
• Tapasztalati képlet (Hill-képlet): C₁₉H₁₇NO₃ · HCl
• CAS-szám: 934389-88-5
• Molekulatömeg: 343.80
• MDL-szám: MFCD00270881
• UNSPSC kód: 12352207
• PubChem Substance ID: 24278828
• NACRES: NA.77

Tulajdonságok

• Terméknév: LY-294,002 hydrochloride, solid, ≥98% (HPLC)
• biológiai forrás: microbial (Staphylococcus roseus)
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: solid
• szín: white to off-white
• oldhatóság: DMSO: >5 mg/mL; H₂O: insoluble
• tárolási hőmérséklet: 2-8°C
• SMILES string: O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
• InChI: 1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
• Nemzetközi kémiai azonosító kulcs: CZQHHVNHHHRRDU-UHFFFAOYSA-N

Leírás

Általános leírás

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Alkalmazás

LY-294,002 hydrochloride has been used in the inhibition of:

• phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
• autophagy in mesenchymal stem cells (MSCs).
• serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

Biokémiai/fiziológiai hatások

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

Tulajdonságok és előnyök

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)