A1260

Amantadine hydrochloride

≥98% (TLC), powder, NMDA receptor antagonist

• Szinonimák: 1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride
• Tapasztalati képlet (Hill-képlet): C₁₀H₁₇N · HCl
• CAS-szám: 665-66-7
• Molekulatömeg: 187.71
• Beilstein: 4198854
• EC-szám: 211-560-2
• MDL-szám: MFCD00074723
• UNSPSC kód: 12352200
• PubChem Substance ID: 24277882
• NACRES: NA.77

Tulajdonságok

• Terméknév: Amantadine hydrochloride,
• Forma: powder
• Minőségi szint: 100
• oldhatóság: H₂O: 50 mg/mL; ethanol: soluble
• kezdeményező: Endo
• SMILES string: Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
• InChI: 1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
• Nemzetközi kémiai azonosító kulcs: WOLHOYHSEKDWQH-SOVZANNPSA-N

Leírás

Általános leírás

Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.

Alkalmazás

Amantadine hydrochloride has been used:

• to determine its effectiveness in reducing surgery-induced cognitive impairment
• to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway
• to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory
• to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
• to determine the pathway of internalization

Biokémiai/fiziológiai hatások

Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Tulajdonságok és előnyök

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H302
• Óvintézkedésre vonatkozó mondatok: P301 + P312 + P330
• Veszélyességi osztályok: Acute Tox. 4 Oral
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Gloves