PHR1876

Valsartan Related Compound B

Pharmaceutical Secondary Standard; Certified Reference Material

• Szinonimák: N-(1-Oxobutyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine, N-butyryl-N-{[2′-(1H-tetrazole-5-yl)-biphenyl-4-yl]methyl}-L-valine, (S)-N-Butyryl-N-{[2′-(1-H-tetrazole-5-yl)-biphenyl-4-yl]methyl}valine
• Tapasztalati képlet (Hill-képlet): C₂₃H₂₇N₅O₃
• CAS-szám: 952652-79-8
• Molekulatömeg: 421.49
• MDL-szám: MFCD19689078
• UNSPSC kód: 41116107
• NACRES: NA.24

Tulajdonságok

• grade: certified reference material; pharmaceutical secondary standard
• Minőségi szint: 300
• Ügynökség: traceable to USP 1708784
• API-család: valsartan
• Analitikai műbizonylat: current certificate can be downloaded
• kiszerelés: pkg of 30 mg
• alkalmazás(ok): pharmaceutical
• Formátum: neat
• tárolási hőmérséklet: 2-8°C
• SMILES string: CCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@@H](C(C)C)C(O)=O
• InChI: 1S/C23H27N5O3/c1-4-7-20(29)28(21(15(2)3)23(30)31)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)22-24-26-27-25-22/h5-6,8-13,15,21H,4,7,14H2,1-3H3,(H,30,31)(H,24,25,26,27)/t21-/m0/s1
• Nemzetközi kémiai azonosító kulcs: OKAQHVJSXLGXET-NRFANRHFSA-N

Leírás

Általános leírás

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the potent, highly selective, and orally active antagonist of the angiotensin II AT1-receptor, valsartan, used widely for the treatment of hypertension.

Alkalmazás

This pharmaceutical secondary standard can also be used as follows:

• Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method for the determination of valsartan and its related impurities in pharmaceutical dosage forms
• Impurity testing of valsartan, amlodipine besylate, and hydrochlorothiazide in their combined dosage form by a stability-indicating ultra-high performance liquid chromatography (UHPLC)
• Simultaneous determination of amlodipine and valsartan in their combined dosage form, in the presence of their degradation products by a gradient reversed phase-liquid chromatographic (RP-LC) method
• Separation and detection of nitrosamines and other related impurities in valsartan and losartan using supercritical fluid chromatography (SFC) in a single run
• Development and validation of a UHPLC method for the estimation of sacubitril, valsartan, and their related impurities in their combined dosage form, following ICH Q2 (R1) guideline

Analízis megjegyzés

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Lábjegyzet

To see an example of a Certificate of Analysis for this material enter LRAB1042 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Biztonsági adatok

• Piktogramok: GHS08,GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H336,H361d
• Óvintézkedésre vonatkozó mondatok: P202 - P261 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• Veszélyességi osztályok: Repr. 2 - STOT SE 3
• Célzott szervek: Central nervous system
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable