PHR1524

Tamsulosin hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Szinonimák: Tamsulosin hydrochloride, (−)-(R)-5-[2-[[2-(o-ethoxy phenoxy)ethyl]amino]propyl]-2-methoxy benzene sulfonamide, monohydrochloride, TAM, 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
• Tapasztalati képlet (Hill-képlet): C₂₀H₂₈N₂O₅S · HCl
• CAS-szám: 106463-17-6
• Molekulatömeg: 444.97
• MDL-szám: MFCD00922997
• UNSPSC kód: 41116107
• PubChem Substance ID: 329823437
• NACRES: NA.24

Tulajdonságok

• grade: certified reference material; pharmaceutical secondary standard
• Minőségi szint: 300
• Ügynökség: traceable to BP 876; traceable to Ph. Eur. Y0000650; traceable to USP 1643260
• API-család: tamsulosin
• Analitikai műbizonylat: current certificate can be downloaded
• kiszerelés: ampule of 1 × 200 mg
• technika/technikák: HPLC: suitable; gas chromatography (GC): suitable
• alkalmazás(ok): pharmaceutical (small molecule)
• format: neat
• tárolási hőmérséklet: -10 to -25°C
• SMILES string: Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O
• InChI: 1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1
• Nemzetközi kémiai azonosító kulcs: ZZIZZTHXZRDOFM-XFULWGLBSA-N
• Géninformáció: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Leírás

Általános leírás

Tamsulosin hydrochloride is a subtypeselective a₁A and a₁D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

Alkalmazás

Tamsulosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biokémiai/fiziológiai hatások

Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

Lábjegyzet

To see an example of a Certificate of Analysis for this material enter LRAC0288 in the slot below. This is an example certificate only and may not be the lot that you receive.

Javasolt termékek

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H302
• Óvintézkedésre vonatkozó mondatok: P264 - P270 - P301 + P312 - P501
• Veszélyességi osztályok: Acute Tox. 4 Oral
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable