C0225000

Calcitriol

European Pharmacopoeia (EP) Reference Standard

• Szinonimák: 1α,25-Dihydroxyvitamin D₃, 1α,25-Dihydroxycholecalciferol, Calcitriol
• Tapasztalati képlet (Hill-képlet): C₂₇H₄₄O₃
• CAS-szám: 32222-06-3
• Molekulatömeg: 416.64
• Beilstein: 7559394
• MDL-szám: MFCD00867079
• UNSPSC kód: 41116107
• PubChem Substance ID: 329774770
• NACRES: NA.24

Tulajdonságok

• biológiai forrás: sheep wool (grease)
• grade: pharmaceutical primary standard
• Ügynökség: EP
• API-család: calcitriol
• form: solid
• gyártó/kereskedő neve: EDQM
• technika/technikák: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• alkalmazás(ok): pharmaceutical (small molecule)
• format: neat
• tárolási hőmérséklet: −20°C
• SMILES string: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• Nemzetközi kémiai azonosító kulcs: GMRQFYUYWCNGIN-NKMMMXOESA-N
• Géninformáció: human ... VDR(7421)

Leírás

Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia.

Calcitriol is a biologically active metabolite of vitamin D, formed via hydroxylation of calcidiol in the kidney.

Alkalmazás

Calcitriol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biokémiai/fiziológiai hatások

Biologically active form of vitamin D₃ in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

Biztonsági adatok

• Piktogramok: GHS06,GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H300 + H310 + H330,H372
• Óvintézkedésre vonatkozó mondatok: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Veszélyességi osztályok: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable