D1530

1α,25-Dihydroxyvitamin D₃

≥99% (HPLC)

• Szinonimák: 1α,25-Dihydroxycholecalciferol, Calcitriol
• Tapasztalati képlet (Hill-képlet): C₂₇H₄₄O₃
• CAS-szám: 32222-06-3
• Molekulatömeg: 416.64
• Beilstein: 7559394
• EC-szám: 250-963-8
• MDL-szám: MFCD00867079
• UNSPSC kód: 12352205
• eCl@ss: 34058003
• PubChem Substance ID: 24893473
• NACRES: NA.79

Tulajdonságok

• Minőségi szint: 300
• Teszt: ≥99% (HPLC)
• Forma: solid
• technika/technikák: HPLC: suitable
• tárolási hőmérséklet: −20°C
• SMILES string: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• Nemzetközi kémiai azonosító kulcs: GMRQFYUYWCNGIN-NKMMMXOESA-N
• Géninformáció: human ... VDR(7421)

Leírás

Biokémiai/fiziológiai hatások

Biologically active form of vitamin D₃ in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Biztonsági adatok

• Piktogramok: GHS06,GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H300 + H310 + H330,H372
• Óvintézkedésre vonatkozó mondatok: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Veszélyességi osztályok: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges