45656

Rotenone

PESTANAL^®, analytical standard

• Tapasztalati képlet (Hill-képlet): C₂₃H₂₂O₆
• CAS-szám: 83-79-4
• Molekulatömeg: 394.42
• Beilstein: 6773081
• EC-szám: 201-501-9
• MDL-szám: MFCD09025614
• UNSPSC kód: 41116107
• PubChem Substance ID: 329756870
• NACRES: NA.24

Tulajdonságok

• grade: analytical standard
• Minőségi szint: 100
• termékcsalád: PESTANAL^®
• eltarthatósági idő: limited shelf life, expiry date on the label
• technika/technikák: HPLC: suitable; gas chromatography (GC): suitable
• bp: 210-220 °C/0.5 mmHg (lit.)
• mp: 159-164 °C (lit.)
• alkalmazás(ok): agriculture; environmental
• format: neat
• SMILES string: COc1cc2OCC3Oc4c5C[C@@H](Oc5ccc4C(=O)C3c2cc1OC)C(C)=C
• InChI: 1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1
• Nemzetközi kémiai azonosító kulcs: JUVIOZPCNVVQFO-HBGVWJBISA-N

Leírás

Általános leírás

Rotenone is a contact insecticide and a slow stomach poison, extremely potent against many insects. It is widely used against Varroa Jacobsoni mite, affecting colonies of honey bees.

Alkalmazás

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Rotenone may be used as an analytical reference standard for the quantification of the analyte in raw honey samples and biological samples using different chromatography techniques.

Biokémiai/fiziológiai hatások

Rotenone is an inhibitor of mitochondrial electron transport at nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. It is readily absorbed through the exoskeletons of arthropods, but poorly absorbed cutaneously or from the gastrointestinal tract of mammals. Rotenone acts as a neurotoxic agent which can produce Parkinson-like condition to serve as an animal model for the study of etiology and interventions. The primary mechanism of action of rotenone is complex I inhibition, followed by the generation of oxidative stress and oxidative damage. Because rotenone is lipophilic, it readily penetrates the brain, where it attaches to and inhibits mitochondrial complex I of electron chain transport (ETC).

Egyéb megjegyzések

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Jogi információk

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Piktogramok: GHS06,GHS09
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H300 + H330,H315,H319,H335,H410
• Óvintézkedésre vonatkozó mondatok: P260 - P264 - P273 - P302 + P352 - P304 + P340 + P310 - P305 + P351 + P338
• Veszélyességi osztályok: Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Célzott szervek: Respiratory system
• Tárolási osztály kódja: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges