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Merck
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616464

Sigma-Aldrich

SB431542

≥97% (HPLC), liquid, TGF-β RI kinase inhibitor, Calbiochem®

Szinonimák:

InSolution TGF-β RI Kinase Inhibitor VI, SB431542

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

Tapasztalati képlet (Hill-képlet):
C22H16N4O3 · 2H2O
CAS-szám:
301836-41-9
Molekulatömeg:
420.42
MDL-szám:
MFCD27976360
UNSPSC kód:
51111800
NACRES:
NA.77

Terméknév

TGF-β RI Kinase Inhibitor VI, SB431542, InSolution, ≥97%

Minőségi szint

100

Teszt

≥97% (HPLC)

Forma

liquid

gyártó/kereskedő neve

Calbiochem®

tárolási körülmény

OK to freeze
desiccated (hygroscopic)
protect from light

kiszállítva

ambient

tárolási hőmérséklet

−20°C

SMILES string

[nH]1c(nc(c1c4cc5c(cc4)OCO5)c3ncccc3)c2ccc(cc2)C(=O)N

InChI

1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)

Nemzetközi kémiai azonosító kulcs

FHYUGAJXYORMHI-UHFFFAOYSA-N

Általános leírás

A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 µM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC50 ≥10 µM in the presence of 10 µM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220).

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Irritant (B)

Fizikai forma

A 100 mM (5 mg/119 µl) solution of SB431542 (Cat. No. 616461) in DMSO.

Feloldás

Following initial thaw, aliquot and freeze (-20°C).

Egyéb megjegyzések

Ikushima, H., et al. 2009. Cell Stem Cell5, 504.
Lin, T., et al. 2009. Nat. Methods6, 805.
Maherali, N. and Hochedlinger, K., 2009. Curr. Biol.19, 1718.
Callahan, J.F., et al. 2002. J. Med. Chem.45, 999.
Inman, G.J., et al. 2002. Mol. Pharmacol.62, 65.
Laping, N.J., et al. 2002. Mol. Pharmacol.62, 58.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Tárolási osztály kódja

10 - Combustible liquids

WGK

WGK 1

Lobbanási pont (F)

188.6 °F - (refers to pure substance)

Lobbanási pont (C)

87 °C - (refers to pure substance)

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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