565850

Shikonin

≥98% (HPLC), solid, Pyruvate kinase inhibitor, Calbiochem^®

• Szinonimák: Shikonin, Pyruvate Kinase Inhibitor II
• Tapasztalati képlet (Hill-képlet): C₁₆H₁₆O₅
• CAS-szám: 517-89-5
• Molekulatömeg: 288.30
• MDL-szám: MFCD00075680
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Terméknév: Shikonin, A naphthoquinone found in the Chinese herb Shiunko.
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: red
• oldhatóság: DMSO: 10 mg/mL
• kiszállítva: ambient
• tárolási hőmérséklet: −20°C
• SMILES string: OC(CC=C(C)C)C1=CC(=O)c2c(c(ccc2O)O)C1=O
• InChI: 1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3
• Nemzetközi kémiai azonosító kulcs: NEZONWMXZKDMKF-UHFFFAOYSA-N

Leírás

Általános leírás

A naphthoquinone found in the Chinese herb Lithospermum erythrorhizon. Possesses significant antibacterial, anti-inflammatory and antitumor activities. Inhibits TNF-α and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αVβ3 and inhibits endothelial cells proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line. Selectively blocks PKM2 (IC₅₀<1 µM) over PKM1 and PKL activities (IC₅₀ in the range of 10-20 µM), and inhibits cancer cell glycolysis.

A naphthoquinone found in the Chinese herb Shiunko. Possesses significant antibacterial, anti-inflammatory, and antitumor activities. Inhibits TNF-α-induced and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin α_vβ₃ and inhibits endothelial cell proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line.

Biokémiai/fiziológiai hatások

Cell permeable: no

Primary Target
TNF-α-induced and B-16 melanoma-induced angiogenesis

Product does not compete with ATP.

Reversible: no

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Egyéb megjegyzések

Chen, J., et al. 2011. Oncogene30, 4297.
Li, H., et al. 1999. Phytother. Res.13, 236.
Yoon, Y., et al. 1999. Planta Med.65, 532.
Hisa, T., et al. 1998. Anticancer Res. 18, 783.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable