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407950

Sigma-Aldrich

Ionomycin free acid

from Streptomyces conglobatus, ≥90% (HPLC), waxy solid, Ca2+ mobile ion carrier, Calbiochem®

Szinonimák:

Ionomycin, Free Acid, Streptomyces conglobatus

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
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About This Item

Tapasztalati képlet (Hill-képlet):
C41H72O9
CAS-szám:
56092-81-0
Molekulatömeg:
709.00
MDL-szám:
MFCD06798385
UNSPSC kód:
12352106
NACRES:
NA.77

Terméknév

Ionomycin, Free Acid, Streptomyces conglobatus, Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is a highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+.

Minőségi szint

100

Teszt

≥90% (HPLC)

Forma

waxy solid

gyártó/kereskedő neve

Calbiochem®

tárolási körülmény

OK to freeze
protect from light

oldhatóság

DMSO: 10 mg/mL
methanol: 10 mg/mL

kiszállítva

ambient

tárolási hőmérséklet

2-8°C

InChI

1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33?,36+,37?,39-,40+,41+/m1/s1

Nemzetközi kémiai azonosító kulcs

PGHMRUGBZOYCAA-OJFQOPKISA-N

Általános leírás

Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
Highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.

Biokémiai/fiziológiai hatások

Cell permeable: no
Primary Target
Mobile ion carrier for Ca2+
Product does not compete with ATP.
Reversible: no

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Harmful (C)

Feloldás

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.

Egyéb megjegyzések

Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol.155, 3297.
Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol.154, 44.
Lee, H.C. 1993. J. Biol. Chem.268, 293.
Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc.101, 3344.
Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem.253, 5892.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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