217699
RO-3306
≥95% (HPLC), solid, Cdk1 inhibitor, Calbiochem®
Szinonimák:
Cdk1 Inhibitor IV, RO-3306
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Tapasztalati képlet (Hill-képlet):
C18H13N3OS2
Molekulatömeg:
351.45
UNSPSC kód:
12352200
NACRES:
NA.77
Javasolt termékek
Terméknév
Cdk1 Inhibitor IV, RO-3306, RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively).
Minőségi szint
Teszt
≥95% (HPLC)
Forma
solid
gyártó/kereskedő neve
Calbiochem®
tárolási körülmény
OK to freeze
protect from light
szín
brown
oldhatóság
DMSO: 10 mg/mL
kiszállítva
ambient
tárolási hőmérséklet
2-8°C
Általános leírás
A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥ 2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. Also available as a 10 mM solution in DMSO (Cat. No. 217721).
Biokémiai/fiziológiai hatások
Cell permeable: yes
Primary Target
Cdk1
Cdk1
Product competes with ATP.
Reversible: no
Target Ki: 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively
Kiszerelés
Packaged under inert gas
Figyelmeztetés
Toxicity: Irritant (B)
Feloldás
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Egyéb megjegyzések
Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA103, 10660.
Jogi információk
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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