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Merck
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217721

Sigma-Aldrich

RO-3306

≥95% (HPLC), liquid, Cdk1 inhibitor, Calbiochem®

Szinonimák:

InSolution Cdk1 Inhibitor IV, RO-3306, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone, 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

Tapasztalati képlet (Hill-képlet):
C18H13N3OS2
Molekulatömeg:
351.45
MDL-szám:
MFCD17392573
UNSPSC kód:
12352200
NACRES:
NA.77

product name

Cdk1 Inhibitor IV, RO-3306, InSolution, ≥95%

Minőségi szint

100

Teszt

≥95% (HPLC)

form

liquid

gyártó/kereskedő neve

Calbiochem®

tárolási körülmény

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

kiszállítva

dry ice

tárolási hőmérséklet

−70°C

Általános leírás

A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 M). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.

Biokémiai/fiziológiai hatások

Cell permeable: yes
Primary Target
Cdk1/B1 and Cdk1/A
Reversible: yes
Secondary Target
Cdk2/E, PKCδ, and SGK
Target Ki: 35 nM and 110 nM for Cdk1/B1 and Cdk1/A,

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Irritant (B)

Fizikai forma

A 10 mM (2 mg/569 L) solution of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699) in DMSO.

Feloldás

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Egyéb megjegyzések

Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA103, 10660.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Tárolási osztály kódja

10 - Combustible liquids

WGK

WGK 2

Lobbanási pont (F)

188.6 °F - closed cup - (refers to pure substance)

Lobbanási pont (C)

87 °C - closed cup - (refers to pure substance)

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

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