178273
Aphidicolin
≥98% (HPLC), solid, DNA polymerase α and δ inhibitor, Calbiochem
Szinonimák:
Aphidicolin
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)
About This Item
Tapasztalati képlet (Hill-képlet):
C20H34O4
CAS-szám:
Molekulatömeg:
338.48
MDL-szám:
UNSPSC kód:
12352200
NACRES:
NA.77
Javasolt termékek
product name
Aphidicolin, Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase.
Minőségi szint
Teszt
≥98% (HPLC)
form
solid
gyártó/kereskedő neve
Calbiochem®
tárolási körülmény
OK to freeze
szín
white
oldhatóság
DMSO: 50 mg/mL
ethanol: soluble
methanol: soluble
kiszállítva
ambient
tárolási hőmérséklet
2-8°C
InChI
1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
Nemzetközi kémiai azonosító kulcs
NOFOAYPPHIUXJR-APNQCZIXSA-N
Általános leírás
A cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3. Also available as a 30 mM solution in DMSO (Cat. No. 504744).
A cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
Biokémiai/fiziológiai hatások
Cell permeable: yes
Primary Target
DNA polymerase α, DNA polymerase δ
DNA polymerase α, DNA polymerase δ
Product does not compete with ATP.
Reversible: no
Figyelmeztetés
Toxicity: Standard Handling (A)
Feloldás
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Egyéb megjegyzések
Borner, M.M., et al. 1995. Cancer Res.55, 2122.
Poluha, W., et al. 1995. Oncogene 10, 185.
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci.345, 311.
Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
Hubermann, J.A. 1981. Cell23, 647.
Poluha, W., et al. 1995. Oncogene 10, 185.
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci.345, 311.
Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
Hubermann, J.A. 1981. Cell23, 647.
Jogi információk
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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