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Merck
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1.01695

SAFC

Benzonase®

suitable for biopharmaceutical production EMPROVE® bio

Gyógyszeripari előállítás

Szinonimák:

Endonuclease from Serratia marcescens

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(4)

About This Item

CAS-szám:
9025-65-4
Enzyme Commission szám:
3.1.30.2 (BRENDA, IUBMB)
MDL-szám:
MFCD00131010
UNSPSC kód:
12352204

biológiai forrás

Serratia marcescens

Minőségi szint

500

rekombináns

expressed in E. coli

termékcsalád

EMPROVE® Bio

Teszt

≥99% (SDS-PAGE)

form

buffered aqueous glycerol solution

koncentráció

≥250 units/μL

pH

8.0 (25 °C in H2O)

alkalmazás(ok)

pharma/biopharma processes

kiszállítva

dry ice

tárolási hőmérséklet

-10 to -25°C

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Általános leírás

Benzonase® endonuclease acts as an unspecific endonuclease, degrading both DNA and RNA to small 3–5 base pairs (< 6 kDa) fragments with no base preference. It is the ideal tool for nucleic acid removal in virus vector and vaccine manufacturing as demanded by regulators. Additionally, the use of Benzonase® endonuclease increases the yield in virus purification, protects downstream chromatography and filter devices from fouling, and reduces feed stream viscosity.

Benzonase® endonuclease is the smart solution for DNA removal in viral vaccine and viral vector production and has proven its value for over 30 years. Balancing efficiency and regulatory compliance by delivering reliability and high-quality due manufacturing under good manufacturing practices (GMP ICH Q7). Our extensive documentation packages of Emprove® dossiers and the availability of a FDA Drug Master File type II, supports you in filing your vaccine manufacturing process to the authorities.
Our SAFC® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Alkalmazás

Used for the removal of nucleic acid from protein samples.

Biokémiai/fiziológiai hatások

Digests native or heat-denatured DNA and RNA.

Jogi információk

Benzonase is a registered trademark of Merck KGaA, Darmstadt, Germany
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Árazás

Tárolási osztály kódja

10 - Combustible liquids

WGK

WGK 1

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Dokumentumtár megtekintése

Cikkek

DNA/RNA Removal in Viral Production

Benzonase®endonuclease efficiently removes nucleic acid contaminants from viral production, crucial for cell and gene therapies and vaccines.

Virus-like Particle (VLP) Vaccine Bioprocessing and Formulation Steps

This technical article breaks down the steps of upstream and downstream bioprocessing and formulation of virus-like particle vaccines.

Related Content

Viral Vector Vaccine Mfg.

A templated process produces live vector vaccines. Challenges: yield loss, filtration, aggregation, scaling. Collaboration overcomes manufacturing hurdles.

Virus-Based Vaccine Manufacturing

Tailored viral vaccine manufacturing addresses virus-specific challenges through collaboration.

Adenovirus Vaccine Manufacturing Process

This technical article breaks down the adenovirus vaccine manufacturing process and provides a case study on developing an accelerated and cost-effective single-use adenoviral vector vaccine.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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